Evidence map›Paper›PMID 40144306›Full record

Articlenpj biomedical innovations2025

Super-lubricous polyethylene glycol hydrogel microspheres for use in knee osteoarthritis treatments.

Samuel Stealey, Ether Dharmesh, Maitreyi Bhagat, Abdul Malik Tyagi, Andrew Schab, Melissa Hong, Damon Osbourn, Yousef Abu-Amer, Paul A Jelliss, Silviya Petrova Zustiak

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in npj biomedical innovations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Samuel StealeyDepartment of Biomedical Engineering, School of Science and Engineering, Saint Louis University, Saint Louis, MO USA.
Ether DharmeshDepartment of Biomedical Engineering, School of Science and Engineering, Saint Louis University, Saint Louis, MO USA.
Maitreyi BhagatDepartment of Chemistry, School of Science and Engineering, Saint Louis University, Saint Louis, MO USA.
Abdul Malik TyagiDepartment of Orthopaedics, Washington University in Saint Louis, Saint Louis, MO USA.
Andrew SchabDepartment of Biomedical Engineering, School of Science and Engineering, Saint Louis University, Saint Louis, MO USA.
Melissa HongDepartment of Chemistry, School of Science and Engineering, Saint Louis University, Saint Louis, MO USA.
Damon OsbournDepartment of Chemistry, School of Science and Engineering, Saint Louis University, Saint Louis, MO USA.
Yousef Abu-AmerDepartment of Orthopaedics, Washington University in Saint Louis, Saint Louis, MO USA.
Paul A JellissDepartment of Chemistry, School of Science and Engineering, Saint Louis University, Saint Louis, MO USA.
Silviya Petrova ZustiakDepartment of Biomedical Engineering, School of Science and Engineering, Saint Louis University, Saint Louis, MO USA.

Funding

Development of Injectable Super-Lubricious Microgels for Sustained Release of Platelet-Rich Plasma to Treat Post-Traumatic OsteoarthritisR01AR081270 · NIAMS · SAINT LOUIS UNIVERSITY · PI Yousef Abu-Amer, Silviya Petrova Zustiak · 2023 to 2026
$2.1M
Regulation of Osteoclastogenesis and Inflammatory OsteolysisR01AR082192 · NIAMS · WASHINGTON UNIVERSITY · PI Yousef Abu-Amer · 2023 to 2026
$1.9M
NIAMS NIH HHS R01 AR081270NIAMS NIH HHS R01 AR082192
6 · The paper itself

Abstract

Knee osteoarthritis (OA) is characterized by cartilage degeneration and significant reduction in lubrication. One strategy to recover the natural lubrication of the synovial fluid is the injection of hydrogel microspheres. Here, we have fabricated polyethylene glycol (PEG)-based hydrogel microspheres via a modified electrospraying setup. To improve throughout, crosslinking of PEG droplets was delayed until after droplet formation was complete. A custom-synthesized super-lubricious copolymer consisting of adhesive dopamine methacrylate (DMA), zwitterionic sulfobetaine methacrylate (SBMA), and fluorescent rhodamine B was used to dip-coat the PEG microspheres. Super-lubricious PEG microspheres coating reduced coefficient of friction by 57% compared to simulated synovial fluid, indicating beneficial lubrication properties. When injected into C57BL6 mice, PEG microspheres exhibited stability for up to 26 d and did not adversely affect mouse behavior. These super-lubricious PEG microspheres offer great promise to reduce the friction that is a hallmark of progressive OA, potentially mitigating the need for total knee arthroplasty.

Indexed as

Biomedical materialsBiomimetic synthesis

Identifiers

PMID40144306
PMCPMC11932927

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.