Evidence map›Paper›PMID 40144255›Full record

ArticleJHLT open2024

Use of mechanical circulatory support and survival for heart and heart-kidney transplant recipients in the new allocation system.

Aurelie Merlo, Hannah F Bensimhon, Patricia P Chang, Zhentao Yu, Randall Watkins, Quefeng Li, Mirnela Byku

Abstract read
In one paragraph

Article in JHLT open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. A Paired Kidney Analysis of Simultaneous Heart-Kidney Transplantation and Kidney Transplantation After Heart Transplantation.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2025
    Article
  4. Intraoperative Hemoadsorption in Heart Transplant Surgery: A 5-Year Experience.Journal of cardiovascular development and disease · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Aurelie MerloDepartment of Surgery, School of Medicine, University of North Carolina, Chapel Hill, North Carolina.
Hannah F BensimhonDivision of Cardiology, Dartmouth University, Hanover, New Hampshire.
Patricia P ChangDivision of Cardiology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina.
Zhentao YuDepartment of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina.
Randall WatkinsDivision of Cardiology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina.
Quefeng LiDepartment of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina.
Mirnela BykuDivision of Cardiology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The 2018 United Network for Organ Sharing organ allocation change aimed to distribute donor hearts to the sickest patients on the waitlist. Whether this change differentially affected outcomes in heart-only vs heart-kidney transplant recipients is unknown. Methods: This study used the Scientific Registry of Transplant Recipients to compare outcomes, including survival, of heart-only and heart-kidney transplant recipients from 2015 to 2021, from the old vs new allocation system, including use of mechanical circulatory support (MCS), prior to transplant. Results: During the study period, 16,696 patients underwent heart transplant alone (9,320 in the old and 7,376 in the new system) and 1,156 patients underwent heart-kidney transplant (529 in the old and 627 in the new system). For both heart and heart-kidney transplant populations, there was a 3- to 5-fold increase in the use of temporary MCS. Heart-only recipients had worse survival when temporary MCS was used in the old allocation system. Heart-only recipients with durable MCS had worse survival both in the old and the new allocation system. There was no difference in survival in heart-kidney recipients in the old vs new allocation system, regardless of MCS use. Conclusions: The new heart allocation system was associated with increased use of temporary MCS in both heart and heart-kidney recipients. However, this change only differentially affected survival in heart-only recipients with improved survival if on temporary MCS, but worse survival if on durable MCS. Unlike prior studies, heart-kidney recipients did not have different outcomes after the heart allocation change, which may reflect outcomes in more current times.

Indexed as

allocationheart-kidney transplantLVADMCStemporary MCS

Identifiers

PMID40144255
PMCPMC11935327

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.