Evidence map›Paper›PMID 40144074›Full record

ArticleMedical science educator2025

Analyzing Question Characteristics Influencing ChatGPT's Performance in 3000 USMLE®-Style Questions.

Michael Alfertshofer, Samuel Knoedler, Cosima C Hoch, Sebastian Cotofana, Adriana C Panayi, Martin Kauke-Navarro, Stefan G Tullius, Dennis P Orgill, William G Austen, Bohdan Pomahac and 1 more

Abstract read
In one paragraph

Article in Medical science educator, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Michael Alfertshofer *Department of Oral and Maxillofacial Surgery, Ludwig-Maximilians-University Munich, Munich, Germany.ORCID 0000-0002-4892-2376
Samuel Knoedler *Division of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA USA.
Cosima C HochDepartment of Otolaryngology, Head and Neck Surgery, Technical University of Munich, Munich, Germany.
Sebastian CotofanaDepartment of Dermatology, Erasmus Hospital, Rotterdam, The Netherlands.
Adriana C PanayiDivision of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA USA.
Martin Kauke-NavarroDivision of Plastic Surgery, Yale New Haven Hospital, Yale School of Medicine, New Haven, CT USA.
Stefan G TulliusDivision of Transplant Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA USA.
Dennis P OrgillDivision of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA USA.
William G AustenDivision of Plastic and Reconstructive Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA USA.
Bohdan PomahacDivision of Plastic Surgery, Yale New Haven Hospital, Yale School of Medicine, New Haven, CT USA.
Leonard KnoedlerDivision of Plastic Surgery, Yale New Haven Hospital, Yale School of Medicine, New Haven, CT USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The potential of artificial intelligence (AI) and large language models like ChatGPT in medical applications is promising, yet its performance requires comprehensive evaluation. This study assessed ChatGPT's capabilities in answering USMLE® Step 2CK questions, analyzing its performance across medical specialties, question types, and difficulty levels in a large-scale question test set to assist question writers in developing AI-resistant exam questions and provide medical students with a realistic understanding of how AI can enhance their active learning. Materials and Methods: A total of Results: ChatGPT answered 57.7% of all questions correctly. Highest performance scores were found in the category "Male Reproductive System" (71.7%) while the lowest were found in the category "Immune System" (46.3%). Lower performance was noted in table-based questions, and a negative correlation was found between question difficulty and performance ( Conclusion: ChatGPT demonstrated proficiency close to the passing threshold for USMLE® Step 2CK. Performance varied by category, question type, and difficulty. These findings aid medical educators make their exams more AI-proof and inform the integration of AI tools like ChatGPT into teaching strategies. For students, understanding the model's limitations and capabilities ensures it is used as an auxiliary resource to foster active learning rather than abusing it as a study replacement. This study highlights the need for further refinement and improvement in AI models for medical education and decision-making.

Indexed as

Artificial intelligenceChatGPTMedical educationQuizUSMLE

Identifiers

PMID40144074
PMCPMC11933601

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.