Evidence map›Paper›PMID 40144066›Full record

ArticleJournal of veterinary research2025

Influence of neurokinin B, dynorphin A and kisspeptin-10 on

Natalia Szysiak, Urszula Kosior-Korzecka, Vincenzo Longo, Krzysztof Patkowski, Monika Greguła-Kania, Aneta Nowakiewicz, Mariola Bochniarz, Andrzej Junkuszew

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of veterinary research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Natalia SzysiakSub-Department of Pathophysiology, Lublin, Poland.ORCID https://orcid.org/0000-0001-5775-2500
Urszula Kosior-KorzeckaSub-Department of Pathophysiology, Lublin, Poland.ORCID https://orcid.org/0000-0002-9894-5103
Vincenzo LongoNational Research Council, Institute of Agricultural Biology and Biotechnology, Research Unit of Pisa, 56124 Pisa, Italy.ORCID https://orcid.org/0000-0001-8972-8564
Krzysztof PatkowskiDepartment of Animal Breeding and Agricultural Advisory, Faculty of Animal Sciences and Bioeconomy, University of Life Sciences in Lublin, 20-950 Lublin, Poland.ORCID https://orcid.org/0000-0003-4113-8981
Monika Greguła-KaniaDepartment of Animal Breeding and Agricultural Advisory, Faculty of Animal Sciences and Bioeconomy, University of Life Sciences in Lublin, 20-950 Lublin, Poland.ORCID https://orcid.org/0000-0003-0448-3815
Aneta NowakiewiczSub-Department of Veterinary Microbiology, Department of Preclinical Veterinary Sciences, Faculty of Veterinary Medicine, Lublin, Poland.ORCID https://orcid.org/0000-0003-3961-5291
Mariola BochniarzSub-Department of Veterinary Microbiology, Department of Preclinical Veterinary Sciences, Faculty of Veterinary Medicine, Lublin, Poland.ORCID https://orcid.org/0000-0002-5447-1655
Andrzej JunkuszewDepartment of Animal Breeding and Agricultural Advisory, Faculty of Animal Sciences and Bioeconomy, University of Life Sciences in Lublin, 20-950 Lublin, Poland.ORCID https://orcid.org/0000-0003-2679-9597

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The hypothalamic neuropeptides kisspeptin-10 (KiSS-10), neurokinin B (NKB), and dynorphin A (Dyn A) play roles in the endocrine regulation of the hypothalamic-pituitary-ovarian (HPO) axis in puberty. Livestock's timely attainment of sexual maturity increases reproductive efficiency and raises profitability. The pituitary relationship between these neuropeptides and gonadotropins in puberty in ewes being undercharacterised. The aim of the study was to analyse their direct effect on gonadotropin secretion by pituitary cells isolated from pubescent ewes. Material and Methods: Cells were incubated in McCoy's 5A medium, either without neuropeptides (as the control) or with 10 Results: Greater LH and FSH secretion was observed after the 4-24 h exposure to respective 10 Conclusion: Kisspeptin-10, NKB and Dyn A had a direct impact on gonadotropin secretion by ovine pituitary cells. However, a detailed explanation of their role in gonadotropin secretion by the anterior pituitary gland in sheep and of their impact on the regulation of the HPO axis during sexual maturation or in the pathomechanism of delayed puberty require further studies.

Indexed as

dynorphin Agonadotropinkisspeptinneurokinin Bpuberty

Identifiers

PMID40144066
PMCPMC11936093

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.