ReviewJHLT open2023
Right or left endomyocardial biopsy? A systematic review with meta-analysis about complications and safety.
Review in JHLT open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Multiparametric cardiac MRI in the diagnosis of transplant rejection in patients after orthotopic heart transplantation.European radiology · 2026Article
- MicroRNAs as diagnostic and prognostic biomarkers for viral myocarditis: A systematic review and meta-analysis.International journal of cardiology. Heart & vasculature · 2026Article
- Expert Consensus and Clinical Pathway Recommendations for Transthyretin Amyloid Cardiomyopathy in Malaysia.International journal of heart failure · 2026Review
- Endomyocardial biopsy in patients with myocarditis-still justified in the CMR era? A single-centre experience.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Diagnostic and Therapeutic Options in Myocarditis and Inflammatory Cardiomyopathy.Biomedicines · 2026Review
- Endomyocardial Biopsy Revisited: Diagnostic Value and Expanding Roles in Cardiac Amyloidosis.Current heart failure reports · 2026Review
- Iatrogenic Right Ventricular Perforation Following an Endomyocardial Biopsy for Fulminant Myocarditis.Cureus · 2025Article
- How should immune checkpoint inhibitor myocarditis be treated?Cardio-oncology (London, England) · 2025Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Endomyocardial biopsy (EMB) is an invasive procedure used to diagnose myocarditis and investigate other nonischaemic cardiomyopathies. However, it is still contentious whether right ventricle endomyocardial biopsy (RV-EMB) is safer than left ventricle endomyocardial biopsy (LV-EMB). Therefore, we aimed to perform an updated meta-analysis comparing the outcomes of LV-EMB vs RV-EMB in patients submitted to this procedure. Methods: We searched PubMed, Embase, and Cochrane Central in January 2023 for studies comparing the outcomes of patients submitted to LV-EMB and/or RV-EMB. Outcomes were major and minor complications after the procedure: death, cardiac tamponade requiring pericardiocentesis, pericardial effusion without pericardiocentesis, stroke, transient ischemic attack, arrhythmias as permanent or transient atrioventricular block, atrial fibrillation, ventricular fibrillation, chest pain and local complications. Statistical analysis was performed using RevMan 5.1.7. Heterogeneity was assessed with I² statistics. The risk of bias of the studies has been evaluated with the ROBINS-I tool. Results: We included 6308 patients from 6 studies. The mean age was 49.8 years, with approximately 70% male patients. All studies were observational prospective or retrospective. Pericardial tamponade and/or pericardial effusion (odds ratio 0.54; 95% confidence interval 0.31-0.93; Conclusions: In conclusion, a minor rate of pericardial perforation was observed during LV-EMB compared to RV-EMB. It was also observed that LV-EMB provides a high diagnostic yield in diagnosing myocarditis and other cardiomyopathies. Lay summary: Endomyocardial biopsy (EMB) is an invasive procedure used to diagnose cardiac diseases. Our aim is to study which side of the heart is safer for this procedure.•Biopsy of left ventricle presented less perforation of the heart wall.•Some studies suggest a better diagnostic performance of the left ventricle biopsy.
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