Refractory ulcers of both legs with psoriasis vulgaris successfully treated with dehydrated human amnion/chorion membrane: A case report.

Soma Nakaso, Hyakuzoh Ueda, Chiemi Kaku, Yuki Ideguchi, Aya Miyama, Rei Ogawa

Abstract readCase Reports

In one paragraph

Article in JPRAS open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Soma NakasoDepartment of Plastic and Aesthetic Surgery, Shonan Kamakura General Hospital, Kanagawa, Japan.

Hyakuzoh UedaDepartment of Plastic and Aesthetic Surgery, Shonan Kamakura General Hospital, Kanagawa, Japan.

Chiemi KakuDepartment of Plastic and Aesthetic Surgery, Shonan Kamakura General Hospital, Kanagawa, Japan.

Yuki IdeguchiDepartment of Plastic and Aesthetic Surgery, Shonan Kamakura General Hospital, Kanagawa, Japan.

Aya MiyamaDepartment of Plastic and Aesthetic Surgery, Shonan Kamakura General Hospital, Kanagawa, Japan.

Rei OgawaDepartment of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with psoriasis are particularly susceptible to skin damage and secondary infections due to impaired skin defenses and chronic inflammation. This case report describes an 80-year-old male with psoriasis vulgaris and a refractory venous stasis ulcer that successfully achieved epithelialization following treatment with dehydrated human amnion/chorion membrane (dHACM; EPIFIX®). Despite initial management involving infection control and wound debridement, the ulcer exhibited minimal improvement until the application of dHACM. Within 4 wk, substantial wound contraction and epithelialization were achieved, eliminating the need for skin grafting. The regenerative properties of dHACM, employed in accordance with the TIMERS framework, facilitated effective wound healing through a minimally invasive approach. This case represents the first documented use of dHACM for a venous ulcer in a patient with psoriasis vulgaris, underscoring its potential as an innovative therapeutic option for managing chronic ulcers.

Indexed as

Human amnion/chorion membranePsoriasis vulgarisRefractory ulcers

Identifiers

PMID40143957

DOI10.1016/j.jpra.2025.02.015

PMCPMC11938081

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.