Evidence map›Paper›PMID 40143915›Full record

ArticleJHLT open2024

Body mass index and mortality following primary graft dysfunction: A Lung Transplant Outcomes Group study.

Rachel M Bennett, John P Reilly, Joshua M Diamond, Edward Cantu, Michael Shashaty, Luke Benvenuto, Jonathan P Singer, Scott M Palmer, Jason D Christie, Michaela R Anderson

Abstract read
In one paragraph

Article in JHLT open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Lung transplantation for interstitial lung disease.Breathe (Sheffield, England) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rachel M BennettDepartment of Medicine, Division of Pulmonary, Allergy, and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania.
John P ReillyDepartment of Medicine, Division of Pulmonary, Allergy, and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania.
Joshua M DiamondDepartment of Medicine, Division of Pulmonary, Allergy, and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania.
Edward CantuDepartment of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania.
Michael ShashatyDepartment of Medicine, Division of Pulmonary, Allergy, and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania.
Luke BenvenutoDepartment of Medicine, Division of Pulmonary, Allergy, and Critical Care, Columbia University, New York, New York.
Jonathan P SingerDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, San Francisco, California.
Scott M PalmerDepartment of Medicine, Division of Pulmonary Medicine, Duke University, Durham, North Carolina.
Jason D ChristieDepartment of Medicine, Division of Pulmonary, Allergy, and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania.
Michaela R AndersonDepartment of Medicine, Division of Pulmonary, Allergy, and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania.

Funding

Cardiology & pulmonary research training grantT32HL007891 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Jason D Christie · 1998 to 2026
$12.0M
Role of visceral adipose tissue in frailty among patients with Idiopathic Pulmonary FibrosisK23HL150280 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI ANDERSON, MICHAELA RESTIVO · 2020 to 2024
$854k
NHLBI NIH HHS K23 HL150280NHLBI NIH HHS L30 HL143645NHLBI NIH HHS T32 HL007891
6 · The paper itself

Abstract

Higher body mass index (BMI) increases the risk of developing primary graft dysfunction (PGD) after lung transplantation; whether BMI is associated with decreased survival after PGD is unknown. We utilized the Lung Transplant Outcomes Group cohort of 1,538 subjects from 2011-2018. We evaluated the association between preoperative BMI and graft survival among subjects with severe PGD using Cox proportional hazards models with linear splines. Models were stratified by center and adjusted for sex, age, Lung Allocation Score, and diagnosis. PGD developed in 383 subjects. Among subjects with PGD, low BMI was associated with increased mortality while high BMI was not associated with differential mortality, compared to normal BMI. Results were similar for 90-day and 1-year survival. While high BMI increases the risk of developing PGD, it does not appear to be associated with survival after PGD. Future work should focus on PGD prevention rather than PGD management in patients with obesity.

Indexed as

body mass indexlung transplant survivalobesityprimary graft dysfunctionunderweight

Identifiers

PMID40143915
PMCPMC11935391

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.