ArticleJHLT open2024
Proteomics early after heart transplantation and relation to coronary intimal changes and prognosis.
Article in JHLT open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Precision Immunosuppression in Heart Transplantation: Biomarker-Guided Therapy Comes of Age.Current heart failure reports · 2026Review
- Single-cell RNA-sequencing identifies unique cell-specific gene expression profiles in high-grade cardiac allograft vasculopathy.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Long-term survival after heart transplantation (HTx) is limited by cardiac allograft vasculopathy (CAV). The pathogenesis of CAV is poorly understood, and treatment has not yet been well-established. In this exploratory study, we aimed to identify novel immune and nonimmune biomarkers correlated to CAV development, and biomarkers predicting CAV-related events. Methods: Using a proteomic panel, 92 cardiovascular disease-related proteins were evaluated in 26 de novo HTx patients at 3 and 12 months post-transplantation. Intima-area changes were assessed using optical coherence tomography. Major adverse cardiac events (MACE) included significant CAV progression, heart failure, and cardiovascular death. Results: The median follow-up was 6.8 years. We found changes in 4 inflammatory biomarkers: matrix metalloproteinase 3 (MMP-3) and matrix metalloproteinase 2 (MMP-2) were significantly increased after 3 months in the group of patients with the highest intima proliferation, and after 12 months in patients experiencing MACE, respectively. Monocyte chemotactic protein 1 (MCP-1) was increased after 12 months in patients experiencing MACE. Platelet-derived growth factor subunit A (PDGF-A) was significantly increased after 3 months in the group of patients with highest intima proliferation. Conclusions: We identified 4 biomarkers that may be associated with CAV development which differed significantly between groups of intima proliferation and MACE; MMP-2, MMP-3, MCP-1, and PDGF-A. Further studies are needed to examine whether our findings offer the basis to seek new markers of graft vasculopathy or treatment options.
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