Evidence map›Paper›PMID 40143844›Full record

ArticleFrontiers in neuroscience2025

Real-time fMRI using multi-band echo-volumar imaging with millimeter spatial resolution and sub-second temporal resolution at 3 tesla.

Stefan Posse, Sudhir Ramanna, Steen Moeller, Kishore Vakamudi, Ricardo Otazo, Bruno Sa de La Rocque Guimaraes, Michael Mullen, Essa Yacoub

Erratum issuedAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Stefan PosseDepartment of Neurology, University of New Mexico, Albuquerque, NM, United States.
Sudhir RamannaDepartment of Radiology, Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States.
Steen MoellerDepartment of Radiology, Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States.
Kishore VakamudiDepartment of Neurology, University of New Mexico, Albuquerque, NM, United States.
Ricardo OtazoDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
Bruno Sa de La Rocque GuimaraesDepartment of Neurology, University of New Mexico, Albuquerque, NM, United States.
Michael MullenDepartment of Radiology, Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States.
Essa YacoubDepartment of Radiology, Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
TRD4 - Ultrahigh Field Engineering and SafetyP41EB027061 · NIBIB · UNIVERSITY OF MINNESOTA · PI Gregory John Metzger, KAMIL UGURBIL · 2019 to 2026
$11.7M
Towards intra-operative guidance in brain tumor surgery using real-time resting-state functional MRIR42NS134505 · NINDS · NEURINSIGHT, LLC · PI Dieter W Dennig, Stefan Posse · 2023 to 2026
$2.2M
High-Speed fMRI of Resting State ConnectivityR21EB018494 · NIBIB · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI POSSE, STEFAN · 2015 to 2016
$459k
High-Frequency Resting State Connectivity fMRIR21EB022803 · NIBIB · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI POSSE, STEFAN · 2017 to 2018
$428k
Concurrent High-Speed fMRI and Diffusion Tensor MRSIR21CA241714 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI POSSE, STEFAN · 2019 to 2021
$374k
NCI NIH HHS P30 CA008748NCI NIH HHS R21 CA241714NIBIB NIH HHS P41 EB027061NIBIB NIH HHS R21 EB018494NIBIB NIH HHS R21 EB022803NINDS NIH HHS R42 NS134505
6 · The paper itself

Abstract

Purpose: In this study we develop undersampled echo-volumar imaging (EVI) using multi-band/simultaneous multi-slab encoding in conjunction with multi-shot slab-segmentation to accelerate 3D encoding and to reduce the duration of EVI encoding within slabs. This approach combines the sampling efficiency of single-shot 3D encoding with the sensitivity advantage of multi-echo acquisition. We describe the pulse sequence development and characterize the spatial-temporal resolution limits and BOLD sensitivity of this approach for high-speed task-based and resting-state fMRI at 3 T. We study the feasibility of further acceleration using compressed sensing (CS) and assess compatibility with NORDIC denoising. Methods: Multi-band echo volumar imaging (MB-EVI) combines multi-band encoding of up to 6 slabs with CAIPI shifting, accelerated EVI encoding within slabs using up to 4-fold GRAPPA accelerations, 2-shot k Results: Image quality and temporal SNR of MB-EVI was comparable to MS-EVI when using 2-3 mm spatial resolution. High sensitivity for mapping task-based activation and resting-state connectivity at short TR was measured. Online deconvolution of T Conclusion: Combining MS-EVI with multi-band encoding enables high overall acceleration factors and provides flexibility for maximizing spatial-temporal resolution and volume coverage. The high BOLD sensitivity of this hybrid MB-EVI approach and its compatibility with online image reconstruction enables high spatial-temporal resolution real-time task-based and resting state fMRI.

Indexed as

compressed sensingecho-volumar imagingfunctional MRImulti-band encodingNORDIC denoisingresting-state connectivitysimultaneous multi slab encodingtask-based activation

Identifiers

PMID40143844
PMCPMC11936983

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.