ArticleAnnals of surgery2026
Impact of Resection Margin Status on Recurrence and Possible Candidates for Adjuvant Radiotherapy in Resected Distal Cholangiocarcinoma.
Article in Annals of surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- The role of resection margin status on recurrence and selection of patients for adjuvant radiotherapy in distal cholangiocarcinoma.Hepatobiliary surgery and nutrition · 2026Article
- Development of a prediction model integrating cardiac ultrasound parameters for cardiac complications after distal cholangiocarcinoma surgery: a retrospective cohort study.BMC medical imaging · 2026Article
- Neoadjuvant Strategies for Patients with Resectable Biliary Tract Cancers: A Review.Current oncology (Toronto, Ont.) · 2025Review
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11 authors.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the prognostic impact of resection margin in distal cholangiocarcinoma (dCC).
backgroundDue to the relatively low prevalence of dCC in Western countries and the use of various definitions of resection margin status, the prognostic impact of bile duct resection margin status remains unclear.
methodsThis study included consecutive patients who underwent curative surgery and were diagnosed with dCC between 2000 and 2022. Bile duct resection margin status was classified as clear margin, low-grade dysplasia (LGD), high-grade dysplasia (HGD), and tumor present.
resultsOf the 587 patients, 506 (86.2%), 17 (2.9%), 42 (7.2%), and 22 (3.7%) patients had clear margin, LGD, HGD, and tumor present at the margin, respectively. In the node-negative group, patients with clear margin (42.5%) had significantly lower 5-year cumulative overall recurrence rates compared with those with LGD (64.3%), HGD (74.4%), and tumor present status (100.0%). However, in the node-positive group, no significant differences were found in the 5-year cumulative recurrence rates among patients with clear margin (68.8%), HGD (91.1%), and tumor present status (75.0%). In addition, among the node-negative group with a non-clear margin, patients who received adjuvant radiotherapy showed significantly lower 5-year cumulative recurrence rates compared with those who did not receive adjuvant radiotherapy (69.5% versus 87.5%, P =0.037).
conclusionsLocal treatment, including surgery and radiotherapy, may be crucial in node-negative patients but may have limited impact in node-positive patients. In node-positive patients, surgery without clinical deterioration, along with the timely initiation of adjuvant chemotherapy, may be crucial.
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