Evidence map›Paper›PMID 40143815›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2025

Choroidal Neovascularization Is Suppressed With Activation of TREM2 in Mononuclear Phagocytes-Brief Report.

Hitomi Yagi, Myriam Boeck, Katherine Neilsen, Jay Yang, Minji Ko, Yohei Tomita, Kazuno Negishi, Zhongjie Fu, Ye Sun, Lois E H Smith

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. [Dual role and therapeutic potential of TREM2 in atherosclerosis].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026
    Review
  3. Review
  4. TREM2-Mediated Myeloid Cells Protect Against Pathological Choroidal Neovascularization.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hitomi YagiDepartment of Ophthalmology, Boston Children's Hospital, Harvard Medical School, MA (H.Y., M.B., K. Neilsen, J.Y., M.K., Y.T., Z.F., Y.S., L.E.H.S.).ORCID 0000-0002-5199-1970
Myriam BoeckDepartment of Ophthalmology, Boston Children's Hospital, Harvard Medical School, MA (H.Y., M.B., K. Neilsen, J.Y., M.K., Y.T., Z.F., Y.S., L.E.H.S.).
Katherine NeilsenDepartment of Ophthalmology, Boston Children's Hospital, Harvard Medical School, MA (H.Y., M.B., K. Neilsen, J.Y., M.K., Y.T., Z.F., Y.S., L.E.H.S.).ORCID 0009-0007-4996-9380
Jay YangDepartment of Ophthalmology, Boston Children's Hospital, Harvard Medical School, MA (H.Y., M.B., K. Neilsen, J.Y., M.K., Y.T., Z.F., Y.S., L.E.H.S.).ORCID 0000-0003-0790-7951
Minji KoDepartment of Ophthalmology, Boston Children's Hospital, Harvard Medical School, MA (H.Y., M.B., K. Neilsen, J.Y., M.K., Y.T., Z.F., Y.S., L.E.H.S.).
Yohei TomitaDepartment of Ophthalmology, Boston Children's Hospital, Harvard Medical School, MA (H.Y., M.B., K. Neilsen, J.Y., M.K., Y.T., Z.F., Y.S., L.E.H.S.).ORCID 0000-0003-1013-5737
Kazuno NegishiDepartment of Ophthalmology, Keio University School of Medicine, Tokyo, Japan (H.Y., Y.T., K. Negishi).ORCID 0000-0002-2892-9810
Zhongjie FuDepartment of Ophthalmology, Boston Children's Hospital, Harvard Medical School, MA (H.Y., M.B., K. Neilsen, J.Y., M.K., Y.T., Z.F., Y.S., L.E.H.S.).ORCID 0000-0002-8182-2983
Ye SunDepartment of Ophthalmology, Boston Children's Hospital, Harvard Medical School, MA (H.Y., M.B., K. Neilsen, J.Y., M.K., Y.T., Z.F., Y.S., L.E.H.S.).ORCID 0000-0002-7674-9056
Lois E H SmithDepartment of Ophthalmology, Boston Children's Hospital, Harvard Medical School, MA (H.Y., M.B., K. Neilsen, J.Y., M.K., Y.T., Z.F., Y.S., L.E.H.S.).ORCID 0000-0001-7644-6410

Funding

Dietary control of angiogenesis in retinopathy modelsR01EY017017 · NEI · BOSTON CHILDREN'S HOSPITAL · PI Zhongjie Fu, Lois Smith · 2006 to 2026
$11.8M
Mouse Neurodevelopmental Behavior CoreU54HD090255 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI POMEROY, SCOTT LOREN · 2016 to 2020
$5.2M
Photoreceptor Determination of Retinal Blood Vessel Growth in RetinopathyR01EY029238 · NEI · BOSTON CHILDREN'S HOSPITAL · PI YE SUN · 2019 to 2026
$2.6M
Serine control of retinal neovascularization in retinopathyR01EY032492 · NEI · BOSTON CHILDREN'S HOSPITAL · PI FU, ZHONGJIE · 2021 to 2025
$2.2M
The Mechanism of Immune-Vascular Crosstalk in RetinopathyR01EY030140 · NEI · BOSTON CHILDREN'S HOSPITAL · PI SUN, YE · 2019 to 2023
$2.0M
Glucose/lipid metabolism and vessel development in phase I ROPR01EY030904 · NEI · BOSTON CHILDREN'S HOSPITAL · PI SMITH, LOIS · 2020 to 2023
$1.7M
NEI NIH HHS R01 EY017017NEI NIH HHS R01 EY029238NEI NIH HHS R01 EY030140NEI NIH HHS R01 EY030904NEI NIH HHS R01 EY032492NICHD NIH HHS U54 HD090255
6 · The paper itself

Abstract

backgroundMononuclear phagocytes contribute to pathological angiogenesis in age-related macular degeneration, a leading worldwide cause of visual impairment. However, the mechanisms that orchestrate the functions of mononuclear phagocytes remain poorly understood. TREM2 (triggering receptor on myeloid cells 2) has been shown to be crucial for the activation of mononuclear phagocytes in atherosclerosis, fatty liver disease, and Alzheimer disease. The objective of this study was to investigate the role of TREM2 in pathological angiogenesis in age-related macular degeneration.

methodsC57BL/6J and

resultsWe found that pharmacological activation of TREM2 suppressed laser-induced choroidal neovessel formation. The activation of TREM2 in mononuclear phagocytes suppressed TNF (tumor necrosis factor) and subsequently promoted phagocytosis.

conclusionsThese findings demonstrate that activation of TREM2 in mononuclear phagocytes suppresses the proinflammatory response, promotes phagocytosis, and impedes choroidal neovessel formation. Our study provides insight into the critical role of TREM2 in pathological angiogenesis.

Indexed as

ChoroidChoroidal NeovascularizationMacrophagesMacular DegenerationMembrane GlycoproteinsPhagocytesReceptors, ImmunologicAnimalsDisease Models, AnimalMaleMiceMice, Inbred C57BLMice, KnockoutPhagocytosisRAW 264.7 CellsSignal TransductionMembrane GlycoproteinsReceptors, ImmunologicTnf protein, mouseTrem2 protein, mouseTumor Necrosis Factor-alphachoroidal neovascularizationmacrophagesmacular degenerationmicrogliaphagocytes

Identifiers

PMID40143815
PMCPMC12017599

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.