Evidence map›Paper›PMID 40143606›Full record

ReviewBasic & clinical pharmacology & toxicology2025

The Cells of the Vasculature: Advances in the Regulation of Vascular Tone in the Brain and Periphery.

Luke S Dunaway, William A Mills, Ukpong B Eyo, Brant E Isakson

Abstract readReview
In one paragraph

Review in Basic & clinical pharmacology & toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. 3D Bioprinting of Blood Vessel Model for Improving Wound Healing.International journal of molecular sciences · 2026
    Article
  6. Review
  7. The machinery of healthy vasodilatation: an overview.Pflugers Archiv : European journal of physiology · 2025
    Review
  8. The machinery of healthy vasoconstriction: an overview.Pflugers Archiv : European journal of physiology · 2025
    Review
  9. Fibromyalgia: Chronic Pain Due to a Blood Dysfunction?International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Luke S DunawayRobert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
William A MillsRobert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
Ukpong B EyoRobert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
Brant E IsaksonRobert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, Virginia, USA.ORCID https://orcid.org/0000-0002-7692-6294

Funding

AHA 25POST1376070NHLBI NIH HHS HL007284NHLBI NIH HHS HL137112NHLBI NIH HHS HL171997NHLBI NIH HHS HL172605NINDS NIH HHS NS119243NINDS NIH HHS NS122782Owen's Family FoundationUVA Brain Institute Postdoctoral Fellowship
6 · The paper itself

Abstract

The vasculature is a complex tissue in which multiple cell types coordinate the regulation of tissue perfusion in response to hemodynamic and biochemical signals. Advances in this field are continuing to deepen our understanding of the relative importance of these cell types through the body. In the peripheral vasculature, tone is generated primarily by smooth muscle cells and regulated by endothelial cells, and neurons. In the brain parenchyma, unique cell types including pericytes, perivascular astrocytes and microglia, also contribute to the regulation of arterial and capillary tone. Here, we provide a cell-by-cell review of the regulation of vascular tone and highlight recent advances in the regulation of vascular tone in both the periphery and cerebral vasculature.

Indexed as

BrainMuscle, Smooth, VascularAnimalsAstrocytesCerebrovascular CirculationEndothelial CellsEndothelium, VascularHumansMicrogliaMyocytes, Smooth MuscleNeuronsPericytesastrocytescerebral blood flowendotheliummicrogliamyogenic tone

Identifiers

PMID40143606
PMCPMC11947641

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.