Evidence map›Paper›PMID 40143604›Full record

ArticleJournal of biochemical and molecular toxicology2025

Promotion of Autophagy and Apoptosis in Colorectal Cancer Exposed to Imatinib and Thymoquinone.

Dalia El-Khouly, Nadia A Thabet, Mohamed Sayed-Ahmed, Mervat M Omran

Abstract read
In one paragraph

Article in Journal of biochemical and molecular toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dalia El-KhoulyDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Ahram Canadian University, 6th of October City, Giza, Egypt.
Nadia A ThabetDepartment of Cancer Biology, Pharmacology Unit, National Cancer Institute, Cairo University, Egypt.
Mohamed Sayed-AhmedDepartment of Cancer Biology, Pharmacology Unit, National Cancer Institute, Cairo University, Egypt.
Mervat M OmranDepartment of Cancer Biology, Pharmacology Unit, National Cancer Institute, Cairo University, Egypt.ORCID http://orcid.org/0000-0003-1643-0104

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer cells possess high proliferative ability and usually override apoptosis and metastasize to distant lesions. Autophagy in cancer cells is a double-edged weapon where a cross-regulation postulation between apoptosis and autophagy exists. The aim of the present study was to investigate the effect of adding Thymoquinone (TQ) to Imatinib (IM) in HCT

Indexed as

ApoptosisAutophagyBenzoquinonesColorectal NeoplasmsImatinib MesylateHCT116 CellsHumansBenzoquinonesImatinib MesylatethymoquinoneAMPKapoptosisautophagyimatinibPar‐4thymoquinone

Identifiers

PMID40143604
PMCPMC11947640

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.