SynthesisEuropean endodontic journal2025
Clinical Outcomes of Biomaterial Scaffolds in Regenerative Endodontic Therapy: A Systematic Review and Meta-analysis.
Synthesis in European endodontic journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy of dental stem cell-derived exosomes for pulp regeneration: a systematic review of clinical, animal, and in vitro studies.Molecular biology reports · 2026Pooled it
- Hyaluronic Acid vs. PRP, PRF, and Collagen in Regenerative Endodontics: A Systematic Review.Journal of clinical medicine · 2026Review
- Root Development Following Bioceramic Material Application in Immature Permanent Teeth: A Case Series With 24-Month Follow-Up.Case reports in dentistry · 2025Article
- The tooth transformer® revolution: autologous dentin biomaterials and platelet concentrates in oral regeneration. A parallel narrative systematic review.Frontiers in dental medicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Blood clot, platelet-rich fibrin, and plasma-rich plasma are the three most commonly used scaffolds in regenerative endodontic therapy. The current study aimed to evaluate the clinical outcomes of plasma-rich plasma (PRP) and platelet-rich fibrin (PRF) scaffolds and blood clot (BC) in regenerative endodontic therapy. For this systematic review and meta-analysis, international databases such as MEDLINE (PubMed and Ovid), Web of Science, and Scopus were searched between January 2013 and November 2023 using keywords relevant to the study objectives. Randomized controlled trials published in English that investigated the effects of BC, PRF, and PRP interventions compared to each other on permanent teeth with a six-month follow-up period were included in the study. The risk of bias was assessed using the Cochrane tool for randomized trials. Data were analyzed using STATA/MP software, employing odds ratios with fixed and random effects models in the meta-analysis. Fourteen randomized clinical trials involving 430 participants were reviewed. The present study did not reveal any statistically significant differences between BC and PRP regarding apical radiolucency healing (OR: -1.30, 95% CI; -2.68, 0.08; p=0.07, I2=0%, p=0.91) and apical closure (OR: -0.29, 95% CI; -1.07, 0.49; p=0.47, I2=32.63%, p=0.20). However, root-length increase in BC was greater compared to PRP (OR: 3.18, 95% CI; 2.78, 3.57; p<0.01) and PRF (OR: 1.75, 95% CI; 1.38, 2.13; p<0.01). The risk of bias was low for all studies, based on the Cochrane tool. BC is the preferred primary scaffold in regenerative endodontic therapy, while PRP and PRF are recommended for cases of severe canal bleeding. (EEJ-2024-05-079).
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