ArticleMedical physics2025
Commissioning of a precision preclinical 200 kV x-ray irradiator based on modular adaptations.
Article in Medical physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- From local validation to global standardization of three-dimensional printing in radiotherapy.Physics and imaging in radiation oncology · 2026Article
- Commissioning of a precision preclinical 200 kV x-ray irradiator based on modular adaptations.Medical physics · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundPreclinical research in radiation oncology encompasses a range of methodologies, including in vitro cell studies and in vivo small animal experiments, as well as in silico studies to evaluate radiation-induced side effects and tumor responses. PURPOSE: This study addresses the need for high-precision x-ray irradiation solutions as reference for preclinical research. Modifications of an industrial kilovoltage x-ray unit, along with the commissioning of a commercial treatment planning system (TPS), aimed to enable reliable irradiation of small animals in a horizontal beam geometry. All advancements enhancing the irradiation framework are made available, offering cost-effective upgrades for existing systems.
methodsAn industrial kilovoltage x-ray unit was equipped with a dual collimation system, featuring a fixed primary and variable secondary collimators with aperture diameters of 5 to 30 mm. Additional modular adaptations were designed and manufactured, including a multimodal mouse bedding unit, a dedicated dosimetry phantom and a quality assurance (QA) phantom. Output factors, percentage depth dose curves and lateral dose profiles were acquired to generate a beam model in the
resultsThe resulting beam model was validated within a maximum dose deviation of 1.7%. Aperture diameters close to potential target diameters were found to be effective for achieving sufficient target coverage in silico, as demonstrated for a 5 mm target with a homogeneity index of (9.9
conclusionsCost-effective adaptations for an kilovoltage x-ray irradiation framework were designed, manufactured and commissioned, and contribute to the accessibility of preclinical irradiation research. These components are integrated into a comprehensive preclinical particle beam platform.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.