SynthesisActa paediatrica (Oslo, Norway : 1992)2025
Recurrence Rate in Children With Arterial Ischemic Stroke: A Systematic Review.
Synthesis in Acta paediatrica (Oslo, Norway : 1992), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
aimWe conducted a systematic review to examine the recurrence rate in children with arterial ischemic stroke, including the recurrence rate according to stroke aetiology.
methodsThis systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses statement. PubMed and Embase were searched for English-language cohort studies published between 1 January 2000 and 19 January 2023, reporting the recurrence rate in children with AIS. Identified studies were screened by two researchers on title/abstract level and full-text level. The risk of bias was assessed using the modified Critical Appraisal Skills Programme checklist.
resultsThe search yielded 28 studies, including 5546 children and 684 neonates. The studies were from 14 different countries with two international cohorts. Reported recurrence rates ranged from 0.0% to 1.9% for neonatal cohorts and 1.1% to 51.9% for childhood cohorts. The median recurrence rate was 10.6% for childhood AIS cohorts. Arteriopathies represented a high-risk aetiology associated with recurrence rates of 0.0%-52.2% with a median recurrence rate of 21.8%.
conclusionThese findings indicated that subgroups of patients possess a higher recurrence risk than others. Differences between studies highlighted the need for systematic approaches to future research on predictors of recurrent AIS.
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