Evidence map›Paper›PMID 40143452›Full record

ReviewDiabetes, obesity & metabolism2025

Developments in albuminuria testing: A key biomarker for detection, prognosis and surveillance of kidney and cardiovascular disease-A practical update for clinicians.

Jelle M Beernink, Dominique van Mil, Gozewijn D Laverman, Hiddo J L Heerspink, Ron T Gansevoort

Abstract readReview
In one paragraph

Review in Diabetes, obesity & metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Trial
  3. Trial
  4. Recommendations for pre-analytical urine sample handling to allow optimal assessment of albuminuria and proteinuria.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2026
    Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Dysregulation of Niacin-Derived NADMedicina (Kaunas, Lithuania) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jelle M BeerninkDepartment of Clinical Pharmacy and Pharmacology, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands.ORCID 0000-0002-4615-9012
Dominique van MilDepartment of Clinical Pharmacy and Pharmacology, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands.
Gozewijn D LavermanDepartment of Internal Medicine/Nephrology, Ziekenhuis Groep Twente, Almelo, the Netherlands.
Hiddo J L HeerspinkDepartment of Clinical Pharmacy and Pharmacology, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands.ORCID 0000-0002-3126-3730
Ron T GansevoortDepartment of Nephrology, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Albuminuria, the abnormal presence of albumin in urine, is a key marker of kidney damage and a strong predictor of kidney and cardiovascular outcomes. Its clinical significance has evolved from early historical observations to its current role in chronic kidney disease (CKD) detection, risk stratification and treatment monitoring. Advances in measurement techniques and evidence from large-scale studies have reinforced its prognostic value, particularly in guiding interventions such as renin-angiotensin-aldosterone system blockade, sodium-glucose cotransporter-2 inhibitors and non-steroidal mineralocorticoid receptor antagonists. Albuminuria assessment is now integrated into CKD staging, cardiovascular risk prediction models and therapy selection. Despite its established utility, challenges remain, including measurement variability, assay standardisation and under-utilisation in clinical practice. This review provides a practical update on albuminuria testing, summarising its historical development, technical aspects and clinical implications, and emphasising its role in CKD management and cardiovascular risk assessment.

Indexed as

AlbuminuriaCardiovascular DiseasesRenal Insufficiency, ChronicBiomarkersHumansPrognosisRisk AssessmentBiomarkersdiabetes complicationscardiovascular diseaseGLP‐1 analoguemacrovascular diseaseSGLT2 inhibitortype 2 diabetes

Identifiers

PMID40143452
PMCPMC12400485

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.