Evidence map›Paper›PMID 40143422›Full record

ArticleAutophagy2025

ATG16L1 WD domain and linker regulates lipid trafficking to maintain plasma membrane integrity to limit influenza virus infection.

Benjamin Bone, Luke Griffith, Matthew Jefferson, Yohei Yamauchi, Thomas Wileman, Penny P Powell

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autophagy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Benjamin BoneBiomedical Research Centre, Norwich Medical School, University of East Anglia, Norwich, Norfolk, UK.
Luke GriffithBiomedical Research Centre, Norwich Medical School, University of East Anglia, Norwich, Norfolk, UK.
Matthew JeffersonBiomedical Research Centre, Norwich Medical School, University of East Anglia, Norwich, Norfolk, UK.
Yohei YamauchiMolecular Medicine Laboratory, Institute of Pharmaceutical Sciences, D-CHAB, ETH Zurich, Zurich, Switzerland.
Thomas WilemanBiomedical Research Centre, Norwich Medical School, University of East Anglia, Norwich, Norfolk, UK.
Penny P PowellBiomedical Research Centre, Norwich Medical School, University of East Anglia, Norwich, Norfolk, UK.ORCID 0000-0002-5347-0490

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The non-canonical functions of autophagy protein ATG16L1 are dependent on a C-terminal WD domain. Recent studies show that the WD domain is required for conjugation of LC3 to single membranes during endocytosis and phagocytosis, where it is thought to promote fusion with lysosomes. Studies in cells lacking the WD domain suggest additional roles in the regulation of cytokine receptor recycling and plasma membrane repair. The WD domain also protects mice against lethal influenza virus

Indexed as

Autophagy-Related ProteinsCell MembraneLipid MetabolismOrthomyxoviridae InfectionsAnimalsAutophagyBiological TransportBrainCholesterolCytokinesEndocytosisEndosomesHumansInfluenza A virusMiceMice, Inbred C57BLAtg16l1 protein, mouseAutophagy-Related ProteinsCholesterolCytokinesPhosphatidylserinesATG16L1 WD domaincholesterolcytokine storminfluenza virusinterferonnon-canonical autophagy

Identifiers

PMID40143422
PMCPMC12366830

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.