Evidence map›Paper›PMID 40143365›Full record

ArticleViruses2025

The Effect of Immunosuppressive Treatment on Torque Teno Virus Load in Lung Transplant Recipients: A Preliminary Study.

Marek Ochman, Dagmara Galle, Anna Kowal, Magdalena Królikowska, Fryderyk Zawadzki, Anita Stanjek-Cichoracka, Anna Łaszewska, Elżbieta Chełmecka, Tomasz Hrapkowicz

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Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Marek OchmanDepartment of Cardiac, Vascular and Endovascular Surgery and Transplantology, Medical University of Silesia in Katowice, 41-800 Zabrze, Poland.ORCID 0000-0002-1410-5845
Dagmara GalleDepartment of Cardiac, Vascular and Endovascular Surgery and Transplantology, Medical University of Silesia in Katowice, 41-800 Zabrze, Poland.ORCID 0000-0003-3313-8084
Anna KowalDepartment of Cardiac, Vascular and Endovascular Surgery and Transplantology, Medical University of Silesia in Katowice, 41-800 Zabrze, Poland.
Magdalena KrólikowskaDepartment of Cardiac, Vascular and Endovascular Surgery and Transplantology, Medical University of Silesia in Katowice, 41-800 Zabrze, Poland.
Fryderyk ZawadzkiDepartment of Pulmonology and Internal Medicine, Wielkopolska Centre for Pulmonology and Thoracic Surgery, 60-569 Poznań, Poland.
Anita Stanjek-CichorackaDepartment of Biophysics, Faculty of Pharmaceutical Sciences, Medical University of Silesia in Katowice, 41-200 Sosnowiec, Poland.
Anna ŁaszewskaLaboratory of Transplant Immunology, Silesian Centre for Heart Diseases, 41-800 Zabrze, Poland.
Elżbieta ChełmeckaDepartment of Medical Statistics, Faculty of Pharmaceutical Sciences, Medical University of Silesia in Katowice, 41-200 Sosnowiec, Poland.ORCID 0000-0002-0111-438X
Tomasz HrapkowiczDepartment of Cardiac, Vascular and Endovascular Surgery and Transplantology, Medical University of Silesia in Katowice, 41-800 Zabrze, Poland.ORCID 0000-0002-8945-7351

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

After transplantation, systematically monitoring and assessing the risk of transplanted organ rejection is crucial. Current methods involving immunosuppressant monitoring, the assessment of organ function, and biopsies are insufficient for predicting rejection. However, regular determination of torque teno virus (TTV) load after transplantation may prove to be a useful parameter for monitoring immunosuppression efficacy. Therefore, we aimed to evaluate TTV load in patients before and after lung transplantation and the kinetics of TTV growth in relation to immunosuppression strength. We included 14 patients (mean age: 49.4 ± 14.0 years) undergoing lung transplantation and determined TTV copy numbers using the commercial ARGENE TTV-R-GENE kit from BioMerieux from the day of transplantation to 180 days post-transplantation. We also developed an empirical immunosuppression unit scale to calculate immunosuppression strength. We observed an average positive correlation between log

Indexed as

DNA Virus InfectionsImmunosuppression TherapyImmunosuppressive AgentsLung TransplantationTorque teno virusViral LoadAdultAgedFemaleGraft RejectionHumansMaleMiddle AgedTransplant RecipientsImmunosuppressive Agentsimmunotherapy biomarkerlung transplantationmolecular biomarkerTTV

Identifiers

PMID40143365
PMCPMC11945901

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.