ArticleViruses2025
The Association of Systemic Inflammatory Response with Hepatitis B Vaccine Unresponsiveness.
Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Systemic Inflammation and the Persistence of Vaccine-Induced Hepatitis B Immunity in Healthcare Workers.Medical science monitor : international medical journal of experimental and clinical research · 2026Observational
- Immunometabolic determinants of hepatitis B vaccine seroprotection among Ethiopian adults.Scientific reports · 2026Article
- Interleukin-12 as a Predictor for Unresponsiveness to the Hepatitis B Vaccine: A Novel Cut-Off Point in Children.Children (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
(1) Background: Hepatitis B virus (HBV) infection remains a major health challenge. Although vaccination protects people from HBV infection, 5-10% of people at risk of HBV infection and associated liver diseases do not respond to vaccination. The association of hematological indices with vaccine response is a crucial contributing factor in HBV-associated liver damage and the outcome of patients. In this context, we clinically assessed the interaction between inflammatory parameters and Hepatitis B vaccine response for the first time. (2) Methods: In total, 90 volunteers (44 non-responders and 46 responders) were included in this retrospective study. The demographic data and the hemogram parameters of the volunteers were recorded and statistically analyzed. Additionally, systemic inflammation index (SII), platelet-to-lymphocyte ratio (PLR), and neutrophil-to-lymphocyte ratio (NLR) were calculated. (3) Results: Our results indicate that higher median levels of white blood cells (8.61), lymphocytes (2.37), neutrophils (5.71), and platelets (280) were determined in the non-responders compared to the responders. SII and NLR indices were significantly higher in the non-responders than in the responders (
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Registered trials
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