Evidence map›Paper›PMID 40143262›Full record

ReviewViruses2025

Torque Teno Virus: Lights and Shades.

Paola Brani, Hafza Zahira Manzoor, Pietro Giorgio Spezia, Andrea Vigezzi, Giuseppe Ietto, Daniela Dalla Gasperina, Claudia Minosse, Annalisa Bosi, Cristina Giaroni, Giulio Carcano and 2 more

Abstract readReview
In one paragraph

Review in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Article
  3. Torque teno virus in the lower respiratory tract: association with immunosuppression but not mortality in severe pneumonia-a multicenter retrospective cohort study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Immune Monitoring Goes Viral - Torque Teno Virus for Immunologic Risk Stratification After Kidney Transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2025
    Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Paola BraniDepartment of Medicine and Technological Innovation, University of Insubria, 21100 Varese, Italy.ORCID 0009-0003-1852-8583
Hafza Zahira ManzoorDepartment of Medicine and Technological Innovation, University of Insubria, 21100 Varese, Italy.
Pietro Giorgio SpeziaLaboratory of Virology and Biosafety Laboratories, National Institute for Infectious Diseases "Lazzaro Spallanzani"-IRCCS, 00149 Rome, Italy.ORCID 0000-0002-6743-014X
Andrea VigezziDepartment of Medicine and Technological Innovation, University of Insubria, 21100 Varese, Italy.ORCID 0000-0003-1543-0460
Giuseppe IettoDepartment of Medicine and Technological Innovation, University of Insubria, 21100 Varese, Italy.ORCID 0000-0001-5029-8173
Daniela Dalla GasperinaDepartment of Medicine and Technological Innovation, University of Insubria, 21100 Varese, Italy.ORCID 0000-0002-1187-6222
Claudia MinosseLaboratory of Virology and Biosafety Laboratories, National Institute for Infectious Diseases "Lazzaro Spallanzani"-IRCCS, 00149 Rome, Italy.ORCID 0000-0001-7833-9539
Annalisa BosiDepartment of Medicine and Technological Innovation, University of Insubria, 21100 Varese, Italy.ORCID 0000-0001-5027-880X
Cristina GiaroniDepartment of Medicine and Technological Innovation, University of Insubria, 21100 Varese, Italy.ORCID 0000-0002-3760-3441
Giulio CarcanoDepartment of Medicine and Technological Innovation, University of Insubria, 21100 Varese, Italy.ORCID 0000-0001-5260-615X
Fabrizio MaggiLaboratory of Virology and Biosafety Laboratories, National Institute for Infectious Diseases "Lazzaro Spallanzani"-IRCCS, 00149 Rome, Italy.ORCID 0000-0001-7489-5271
Andreina BajDepartment of Medicine and Technological Innovation, University of Insubria, 21100 Varese, Italy.ORCID 0000-0003-0088-2712

Funding

Italian Ministry of Health "Ricerca Corrente - Linea 1 - INMI L. Spallanzani I.R.C.C.S." funding and by the European Union's Horizon 2020 research and innovation programme 896932
6 · The paper itself

Abstract

Torque Teno Virus (TTV) is a highly prevalent non-pathogenic DNA virus whose plasma levels may be related to the host's immune status. TTV gained attention about 25 years ago, but its replication is not fully understood, nor is its relationship with the host's immune system. Despite this lack of knowledge, TTV is currently being investigated as a functional biomarker of the immune system in patients with immunological damage and inflammatory diseases. Monitoring TTV viral load over time may help clinicians in making therapeutic decisions regarding immunosuppression as well as the likelihood of infectious complications. This review summarizes what we do and do not know about this enigmatic virus.

Indexed as

DNA Virus InfectionsTorque teno virusAnimalsHumansViral LoadVirus Replicationanellovirusesimmune markerimmunocompromisedsolid organ transplanttorque teno virus (TTV)transplantationviral load

Identifiers

PMID40143262
PMCPMC11945719

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.