Evidence map›Paper›PMID 40143254›Full record

ArticleViruses2025

Whole-Genome Analysis of G2P[4] Rotavirus Strains in China in 2022 and Comparison of Their Antigenic Epitopes with Vaccine Strains.

Ruyi Che, Jiaxin Fan, Guangping Xiong, Lingshan Kong, Mengjie Dong, Yi Li, Peng Wang, Jianguang Fu, Zhenlu Sun, Song Liu and 5 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ruyi CheNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), NHC Key Laboratory for Medical Virology and Viral Disease, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102200, China.ORCID 0009-0004-5761-8204
Jiaxin FanNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), NHC Key Laboratory for Medical Virology and Viral Disease, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102200, China.
Guangping XiongNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), NHC Key Laboratory for Medical Virology and Viral Disease, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102200, China.
Lingshan KongNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), NHC Key Laboratory for Medical Virology and Viral Disease, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102200, China.ORCID 0009-0007-1884-6193
Mengjie DongNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), NHC Key Laboratory for Medical Virology and Viral Disease, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102200, China.
Yi LiHenan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China.
Peng WangGansu Provincial Center for Disease Control and Prevention, Lanzhou 730000, China.
Jianguang FuJiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.ORCID 0000-0003-0424-7492
Zhenlu SunYantai Center for Disease Control and Prevention, Yantai 264003, China.
Song LiuShandong Center for Disease Control and Prevention, Jinan 266000, China.
Caixia LiGuangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China.
Xuan FengShaanxi Provincial Center for Disease Control and Prevention, Xi'an 710054, China.
Xiaoman SunNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), NHC Key Laboratory for Medical Virology and Viral Disease, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102200, China.
Dandi LiNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), NHC Key Laboratory for Medical Virology and Viral Disease, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102200, China.
Zhaojun DuanNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), NHC Key Laboratory for Medical Virology and Viral Disease, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102200, China.ORCID 0000-0003-3090-4150

Funding

National Key Research and Development Program 2018YFC1200602National Key Research and Development Program 2022YFC2304302National Natural Science Foundation of China 21934005
6 · The paper itself

Abstract

Group A rotavirus (RVA) is the leading cause of acute gastroenteritis in infants and young children worldwide. To elucidate the molecular epidemiology of G2P[4] rotavirus in China and the protective effects of vaccines, whole-genome analysis of 13 G2P[4] RVA strains collected from China in 2022 was performed. Twelve strains possessed the typical DS-1-like genome constellation G2-P[4]-I2-R2-C2-M2-A2-N2-T2-E2-H2. Only GS2265 possessed the genome constellation G2-P[4]-12-R2-C2-M2-A2-N2-T2-E1-H2. With the exception of the NSP4 segment of GS2265, all other sequences of the 13 G2P[4] RVA strains clustered within the same lineage on phylogenetic analysis. However, QD2210 and SX2205 were grouped into different branches compared to the other strains. In the VP7 antigenic epitopes, four residues differed from the RotaTeq G2 strain; specifically, A87T and D96N in the 7-1a region and S213D and S242N in the 7-1b region. Comparison of the current G2P[4] RVA strains circulating in China with those circulating globally revealed a high degree of sequence identity. High genetic variability among the newly characterized G2P[4] RVA strains suggest the strains evolve fast. Finally, our data suggest that the multivalent RotaTeq vaccine could have provided better protection than the monovalent Rotarix and LLR.

Indexed as

Antigens, ViralEpitopesGenome, ViralRotavirusRotavirus InfectionsRotavirus VaccinesCapsid ProteinsChild, PreschoolChinaGastroenteritisGenotypeHumansInfantMolecular EpidemiologyPhylogenyWhole Genome SequencingAntigens, ViralCapsid ProteinsEpitopesRotavirus Vaccinesantigenic epitopeChinaG2P[4]rotaviruswhole-genome analysis

Identifiers

PMID40143254
PMCPMC11945518

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.