Evidence map›Paper›PMID 40143221›Full record

ArticleViruses2025

A Case of Severe Respiratory Failure Caused by Metapneumovirus and Influenza Virus in a Patient with HIV Infection.

Luca Pipitò, Chiara Vincenza Mazzola, Eleonora Bono, Claudia Gioè, Giovanni M Giammanco, Celestino Bonura, Antonio Cascio

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Luca PipitòDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "G. D'Alessandro", University of Palermo, 90133 Palermo, Italy.ORCID 0000-0002-1871-4285
Chiara Vincenza MazzolaDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "G. D'Alessandro", University of Palermo, 90133 Palermo, Italy.ORCID 0009-0003-8975-4916
Eleonora BonoDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "G. D'Alessandro", University of Palermo, 90133 Palermo, Italy.
Claudia GioèInfectious and Tropical Disease Unit, AOU Policlinico "P. Giaccone", 90133 Palermo, Italy.
Giovanni M GiammancoDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "G. D'Alessandro", University of Palermo, 90133 Palermo, Italy.ORCID 0000-0002-7874-6289
Celestino BonuraDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "G. D'Alessandro", University of Palermo, 90133 Palermo, Italy.ORCID 0000-0002-6250-9203
Antonio CascioDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "G. D'Alessandro", University of Palermo, 90133 Palermo, Italy.ORCID 0000-0002-1992-1796

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHuman metapneumovirus (HMPV) is a significant cause of respiratory infections, particularly in children, the elderly, and immunocompromised individuals. However, data on HMPV infection in people living with HIV (PLWH) are limited, and cases of co-infection with influenza A virus in this population have not been previously described. CASE PRESENTATION: We reported the case of a 73-year-old HIV-positive man with multiple comorbidities, including insulin-dependent diabetes mellitus, who presented with fever, asthenia, and glycometabolic decompensation. Despite an initially unremarkable chest computed tomography (CT) scan, the patient developed progressive respiratory failure, requiring high-flow oxygen therapy. Molecular testing using the BIOFIRE

conclusionsThis case highlights the potential severity of HMPV and influenza A co-infection in PLWH, emphasizing the importance of molecular diagnostics in distinguishing viral from bacterial infections. Rapid and accurate pathogen identification is essential for guiding appropriate antimicrobial stewardship and optimizing patient outcomes in community-acquired pneumonia.

Indexed as

CoinfectionHIV InfectionsInfluenza, HumanMetapneumovirusParamyxoviridae InfectionsRespiratory InsufficiencyAgedHumansInfluenza A virusMaleantimicrobial stewardshipcommunity-acquired pneumonia (CAP)HIV infectionHMPVhuman metapneumovirusinfluenza A virusmolecular diagnosticsmultiplex PCRsevere pneumonia

Identifiers

PMID40143221
PMCPMC11945452

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.