Evidence map›Paper›PMID 40143181›Full record

ArticlePharmaceuticals (Basel, Switzerland)2025

Mechanistic and Molecular Insights into Empagliflozin's Role in Ferroptosis and Inflammation Trajectories in Acetaminophen-Induced Hepatotoxicity.

Aisha Alhaddad, Esraa M Mosalam, Hind S AboShabaan, Amany Said Sallam, Marwa M Mahfouz, Enas Elhosary, Asmaa A Mohammed, Ebtehal M Metwally, Moataz A Shaldam, Mai El-Sayed Ghoneim

Abstract read
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In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
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  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Aisha AlhaddadDepartment of Pharmacology and Toxicology, College of Pharmacy, Taibah University, Medina 42353, Saudi Arabia.
Esraa M MosalamBiochemistry Department, Faculty of Pharmacy, Menoufia University, Shebin El-Kom 32511, Menoufia, Egypt.ORCID 0000-0003-4630-4125
Hind S AboShabaanClinical Pathology Department, National Liver Institute Hospital, Menoufia University, Shebin El-Kom 32511, Menoufia, Egypt.ORCID 0009-0007-0390-9454
Amany Said SallamDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Menoufia University, Shebin El-Kom 32511, Menoufia, Egypt.
Marwa M MahfouzDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Menoufia University, Shebin El-Kom 32511, Menoufia, Egypt.
Enas ElhosaryDepartment of Pathology, Faculty of Medicine, Helwan University, Cairo 11795, Egypt.
Asmaa A MohammedDepartment of Pharmacology and Toxicology, Faculty of Pharmacy Girls, AL Azhar University, Cairo 11651, Egypt.
Ebtehal M MetwallyMedical Physiology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom 32511, Menoufia, Egypt.
Moataz A ShaldamDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh 12613, Kafrelsheikh, Egypt.ORCID 0000-0002-0420-4364
Mai El-Sayed GhoneimDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, University of Sadat City (USC), Sadat City 32897, Monufia Governorate, Egypt.ORCID 0000-0002-5651-5877

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

acetaminophenempagliflozinferroptosisinflammationoxidative stressSTAT3

Identifiers

PMID40143181
PMCPMC11944739

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.