Evidence map›Paper›PMID 40143110›Full record

ArticlePharmaceuticals (Basel, Switzerland)2025

Intravenous vs. Oral Dose Comparison of Ibuprofen and Tramadol Combinations-Enantiomers, Metabolite, Linearity, and Sex-Related Effects: A Pharmacokinetics Randomized Clinical Trial.

Carmen Portolés-Díez, María Rosario Salas-Butrón, Ana Ascaso-Del-Rio, Ana B Rivas-Paterna, Leonor Laredo-Velasco, Carlos Calandria, Nuria Sanz, Annik Bergeron, Luis Santé, Emilio Vargas-Castrillón and 1 more

Abstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Role of Pharmacogenetics on Tramadol Pharmacokinetics: A Population Pharmacokinetic Model.European journal of drug metabolism and pharmacokinetics · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Carmen Portolés-DíezServicio de Anestesiología, Reanimación y Tratamiento del Dolor, Hospital Clínico San Carlos, 28040 Madrid, Spain.ORCID 0000-0001-7750-4133
María Rosario Salas-ButrónInstituto de Investigación Sanitaria del Hospital Clínico San Carlos, 28040 Madrid, Spain.
Ana Ascaso-Del-RioInstituto de Investigación Sanitaria del Hospital Clínico San Carlos, 28040 Madrid, Spain.
Ana B Rivas-PaternaInstituto de Investigación Sanitaria del Hospital Clínico San Carlos, 28040 Madrid, Spain.
Leonor Laredo-VelascoInstituto de Investigación Sanitaria del Hospital Clínico San Carlos, 28040 Madrid, Spain.
Carlos CalandriaFarmalider SA, 28108 Madrid, Spain.
Nuria SanzFarmalider SA, 28108 Madrid, Spain.
Annik BergeronAltasciences, Laval, QC H7V 4B3, Canada.
Luis SantéServicio de Anestesiología, Reanimación y Tratamiento del Dolor, Hospital Clínico San Carlos, 28040 Madrid, Spain.ORCID 0000-0001-5300-5030
Emilio Vargas-CastrillónInstituto de Investigación Sanitaria del Hospital Clínico San Carlos, 28040 Madrid, Spain.ORCID 0000-0003-4828-6004
Antonio Portolés-PérezInstituto de Investigación Sanitaria del Hospital Clínico San Carlos, 28040 Madrid, Spain.ORCID 0000-0002-5646-5275

Funding

Farmalider SA 17/160-R_M
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

analgesics associationbioavailabilityclinical trialnon-steroidal analgesicsO-desmethyl-Tramadolopiates equipotent dosesopioids

Identifiers

PMID40143110
PMCPMC11944613

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.