Evidence map›Paper›PMID 40143006›Full record

ReviewPharmaceutics2025

Direct Oral Anticoagulants for the Treatment of Unusual-Site Venous Thrombosis: An Update.

Anabel Franco-Moreno, Elena Madroñal-Cerezo, Ana Martínez-Casa-Muñoz, Judith Ortiz-Sánchez, Cristina Lucía Ancos-Aracil

Abstract readReview
In one paragraph

Review in Pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Anabel Franco-MorenoVenous Thromboembolism Unit, Department of Internal Medicine, Hospital Universitario Infanta Leonor, Avenida Gran Via del Este, 80, 28031 Madrid, Spain.ORCID 0000-0003-1061-0200
Elena Madroñal-CerezoVenous Thromboembolism Unit, Department of Internal Medicine, Hospital Universitario de Fuenlabrada, Camino del Molino, 2, Fuenlabrada, 28942 Madrid, Spain.
Ana Martínez-Casa-MuñozHospital Universitario Gregorio Marañón, Calle del Dr. Esquerdo, 46, 28007 Madrid, Spain.
Judith Ortiz-SánchezVenous Thromboembolism Unit, Hospital Universitario de Torrejón, Calle Mateo Inurria, Torrejón de Ardoz, 28850 Madrid, Spain.
Cristina Lucía Ancos-AracilVenous Thromboembolism Unit, Department of Internal Medicine, Hospital Universitario de Fuenlabrada, Camino del Molino, 2, Fuenlabrada, 28942 Madrid, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Direct oral anticoagulants (DOACs) have emerged as the preferred oral anticoagulant therapy for patients with deep vein thrombosis of the lower extremities and pulmonary embolism. DOACs offer several advantages over vitamin K antagonists, including fixed dosage, fewer drug interactions, faster onset of action, and a lower risk of major bleeding, especially intracranial. Although evidence on the use of DOACs in unusual-site venous thrombosis (USVT) is limited, their use in such cases is becoming increasingly common. This narrative review examines the evidence derived from randomized controlled trials, and large observational studies focused on the use of the DOACs in USVT, including cerebral, splanchnic, upper extremity, ovarian, renal, and retinal vein thrombosis. In addition, it also provides practical advice for their use in these clinical settings according to the updated scientific literature.

Indexed as

direct oral anticoagulantsrandomized clinical trialsreviewunusual-site thrombosisvenous thrombosis

Identifiers

PMID40143006
PMCPMC11944374

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.