Evidence map›Paper›PMID 40142991›Full record

ReviewPharmaceutics2025

Drug Delivery Systems Based on Dendritic-Cell-Derived Exosomes.

Lihua Chen, Jie Zhang, Yueyan Huang, Xiaoqin Zhang, Guoqing Zhang, Shuaizhi Kong, Jianqing Gao, Xiaojuan Zhang, Baoyue Ding

Abstract readReview
In one paragraph

Review in Pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
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  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lihua ChenCollege of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China.
Jie ZhangJiaxing Key Laboratory for Photonanomedicine and Experimental Therapeutics, Department of Pharmaceutics, College of Medicine, Jiaxing University, No. 118 Jiahang Road, Jiaxing 314001, China.
Yueyan HuangJiaxing Key Laboratory for Photonanomedicine and Experimental Therapeutics, Department of Pharmaceutics, College of Medicine, Jiaxing University, No. 118 Jiahang Road, Jiaxing 314001, China.
Xiaoqin ZhangJiaxing Key Laboratory for Photonanomedicine and Experimental Therapeutics, Department of Pharmaceutics, College of Medicine, Jiaxing University, No. 118 Jiahang Road, Jiaxing 314001, China.
Guoqing ZhangCollege of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China.
Shuaizhi KongCollege of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China.
Jianqing GaoJiaxing Key Laboratory for Photonanomedicine and Experimental Therapeutics, Department of Pharmaceutics, College of Medicine, Jiaxing University, No. 118 Jiahang Road, Jiaxing 314001, China.
Xiaojuan ZhangJiaxing Key Laboratory for Photonanomedicine and Experimental Therapeutics, Department of Pharmaceutics, College of Medicine, Jiaxing University, No. 118 Jiahang Road, Jiaxing 314001, China.
Baoyue DingJiaxing Key Laboratory for Photonanomedicine and Experimental Therapeutics, Department of Pharmaceutics, College of Medicine, Jiaxing University, No. 118 Jiahang Road, Jiaxing 314001, China.ORCID 0000-0002-5403-6354

Funding

Basic Public Welfare Research Project of Zhejiang Province LTGY24H160007, LGF20H300012, LGC21B050011 and LQN25H160047the National Natural Science Foundation of China 81872220 and 81703437the Science and Technology Bureau of Jiaxing 2024AY10042 and 2024AY10009
6 · The paper itself

Abstract

Exosomes, spherical lipid-bilayered particles secreted by cells, have recently emerged as a novel and highly promising drug delivery system, attracting extensive attention in the field of biomedical research. Dendritic-cell-derived exosomes (DC-Exos) possess surface protein and ligands characteristic of DC cells, such as functional MHC-I and MHC-II, CD80, CD86. These components play a crucial role in immune responses, facilitating antigen uptake, presentation, and the activation of antigen-specific CD4 and CD8 T cells. These properties make them striking and excellent drug delivery vehicles for use in various immune diseases and cancer therapy. This review summarizes and discusses the characteristics, current methods and types of drug loading of DC-Exos. Its surface modifications and application in disease treatment were also discussed, aiming to motivate the development of exosome-based theranostic nanoplatforms and nanotechnology for improved healthcare treatments.

Indexed as

dendritic cellsdrug delivery systemexosomesimmunotherapy

Identifiers

PMID40142991
PMCPMC11946698

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.