Evaluation of Complex Drug Interactions Between Elexacaftor-Tezacaftor-Ivacaftor and Statins Using Physiologically Based Pharmacokinetic Modeling.

Eunjin Hong, Peter S Chung, Adupa P Rao, Paul M Beringer

Abstract read

In one paragraph

Article in Pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Eunjin HongCollege of Pharmacy, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam-si 13488, Gyeonggi-do, Republic of Korea.ORCID 0000-0002-6696-3948

Peter S ChungDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Keck School of Medicine, University of Southern California, 1975 Zonal Ave, Los Angeles, CA 90033, USA.

Adupa P RaoDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Keck School of Medicine, University of Southern California, 1975 Zonal Ave, Los Angeles, CA 90033, USA.

Paul M BeringerUSC Anton Yelchin CF Clinic, 1510 San Pablo St., Los Angeles, CA 90033, USA.ORCID 0000-0002-3744-3310

Funding

Anton Yelchin Foundation N/ACHA University's Industry Academic Cooperation Foundation CHA-202301140001Cystic Fibrosis Foundation BERING21AO

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

cystic fibrosis (CF)cystic fibrosis transmembrane conductance regulator (CFTR) modulatorcytochrome P450 isoenzymes (CYP)drug–drug interactionsorganic anion-transporting polypeptides (OATPs)physiologically based pharmacokinetic (PBPK)Statin

Identifiers

PMID40142982

DOI10.3390/pharmaceutics17030318

PMCPMC11945117

What OpenQuestion holds

Textmetadata

LicenceCC BY

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.