ReviewPharmaceutics2025
An Overview on the Role of Ionic Liquids and Deep Eutectic Solvents in Oral Pharmaceuticals.
Review in Pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Neurobehavioural Effects of the Methylimidazolium Ionic Liquid M8OI in Rats.Journal of xenobiotics · 2026Article
- Molecular interactions, solubility, and cytotoxic activity of 4‑hydroxycoumarin in choline chloride‑based acidic deep eutectic solvents.Scientific reports · 2026Article
- Article
- Strategies for overcoming multiple barriers of oral administration of protein and peptide therapeutics.Materials today. Bio · 2026Review
- Integrating green synthesis and liquid-liquid extraction of lidocaine in deep eutectic solvents.RSC medicinal chemistry · 2026Article
- Polymer-Embedded Deep Eutectic Solvents: Mechanistic Insights into Storage and Supersaturation Stabilization.Polymers · 2026Article
- Advancements in Therapeutic Deep Eutectic Solvents as Multifunctional Transdermal Delivery Systems.Pharmaceutics · 2026Review
- Ionic Liquids as Antibacterial and Drug Delivery Agents: How Cationic Amphiphilic Structure Controls Morphology Changes in Lipid Bilayers and Penetration Mechanism.The journal of physical chemistry. B · 2026Article
- Insights into the colloidal and structural stability of Atezolizumab with nonpolar amino acid-based ionic liquids under multiple stresses: phase two.RSC advances · 2026Article
- Review
- Solvatochromic Polarity, Physicochemical Properties, and Spectral Analysis of New Triple NADES-Based on Urea-Glycerol.Molecules (Basel, Switzerland) · 2026Article
- NADES-Mediated Deposition of Potential Biomimetic Drug-Loaded Polypyrrole on Biomedical Ti20Zr5Ta2Ag.Biomimetics (Basel, Switzerland) · 2025Article
- Natural deep eutectic solvents (NaDES): green solvents for pharmaceutical applications and beyond.Green chemistry : an international journal and green chemistry resource : GC · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over the past twenty years, ionic liquids (ILs) and deep eutectic solvents (DESs) have gained recognition across various fields, including catalysis, extraction and purification, materials science, and biotechnology. Notably, the use of ILs and DESs in pharmaceutical research, especially in drug delivery, has seen remarkable expansion over the past decade. This review offers a comprehensive analysis of ILs and DESs specifically designed for the oral administration of drugs having unfavorable biopharmaceutical properties. The classification and characteristics of ILs and DESs, along with their newer natural (Bio-ILs and NaDESs) and therapeutic subcategories (API-ILs and TheDESs) are outlined. Additionally, a further subgroup of ILs, known as surface active ionic liquids (SAILs), is described. Then, a detailed examination of the available manufacturing methods in a sustainable, time-consuming, and scalable perspective, and toxicity concerns in relation to their subdivision are evaluated. Finally, their specific applications in oral drug delivery, whether used as neat solvents or converted into administrable dosage forms, are analyzed and discussed. Despite the significant advancements in recent years regarding the use of these solvents in oral drug delivery, there are still many aspects that need further investigation. These include their interaction with biological systems (gastrointestinal fluids and mucosa), their long-term stability, and the development of effective drug delivery systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.