Evidence map›Paper›PMID 40142961›Full record

ArticlePharmaceutics2025

Amikacin Dosing Adjustment in Critically Ill Oncologic Patients: A Study with Real-World Patients, PBPK Analysis, and Digital Twins.

Juliana Queiroz da Silva, Natália Valadares de Moraes, Rita Estrela, Diogenes Coelho, Diego Feriani, Karen Migotto, Pedro Caruso, Ivan Leonardo França E Silva, Daiane de Araujo Oliveira, João Paulo Telles and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Juliana Queiroz da SilvaLaboratory of Pharmacometrics (LabFarma), Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.
Natália Valadares de MoraesCenter for Pharmacometrics and Systems Pharmacology, Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando, FL 32827, USA.ORCID 0000-0002-4389-058X
Rita EstrelaLaboratory of Pharmacometrics (LabFarma), Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.
Diogenes CoelhoDepartment of Infectious Diseases, AC Camargo Cancer Center, São Paulo 01509-010, Brazil.ORCID 0009-0003-2285-6918
Diego FerianiDepartment of Infectious Diseases, AC Camargo Cancer Center, São Paulo 01509-010, Brazil.ORCID 0000-0002-3733-6048
Karen MigottoDepartment of Pharmacy, AC Camargo Cancer Center, São Paulo 01509-010, Brazil.
Pedro CarusoDepartment of Intensive Care Medicine, AC Camargo Cancer Center, São Paulo 01509-010, Brazil.
Ivan Leonardo França E SilvaDepartment of Infectious Diseases, AC Camargo Cancer Center, São Paulo 01509-010, Brazil.
Daiane de Araujo OliveiraDepartment of Pharmacy, AC Camargo Cancer Center, São Paulo 01509-010, Brazil.
João Paulo TellesDepartment of Infectious Diseases, AC Camargo Cancer Center, São Paulo 01509-010, Brazil.ORCID 0000-0003-4078-2046
Fernanda de Lima MoreiraLaboratory of Pharmacometrics (LabFarma), Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.ORCID 0000-0001-7699-2665

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

aminoglycosidedose adjustmentMIPDnephrotoxicitypharmacokinetics

Identifiers

PMID40142961
PMCPMC11944554

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.