Evidence map›Paper›PMID 40142528›Full record

ReviewMicroorganisms2025

Extracellular Vesicles in Bacteria, Archaea, and Eukaryotes: Mechanisms of Inter-Kingdom Communication and Clinical Implications.

Maria Di Naro, Giulio Petronio Petronio, Farwa Mukhtar, Marco Alfio Cutuli, Irene Magnifico, Marilina Falcone, Natasha Brancazio, Antonio Guarnieri, Roberto Di Marco, Daria Nicolosi

Abstract readReview
In one paragraph

Review in Microorganisms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Microbial extracellular vesicles in the lung: friends in health, agents in disease.Extracellular vesicles and circulating nucleic acids · 2026
    Review
  7. Review
  8. Review
  9. A Mechanistic Study ofJournal of microbiology and biotechnology · 2025
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Maria Di NaroDepartment of Medicina e Scienze della Salute "V. Tiberio", Università degli Studi del Molise, 86100 Campobasso, Molise, Italy.
Giulio Petronio PetronioDepartment of Medicina e Scienze della Salute "V. Tiberio", Università degli Studi del Molise, 86100 Campobasso, Molise, Italy.ORCID 0000-0002-5098-7785
Farwa MukhtarDepartment of Medicina e Scienze della Salute "V. Tiberio", Università degli Studi del Molise, 86100 Campobasso, Molise, Italy.
Marco Alfio CutuliAileens Pharma S.r.l., 20834 Nova Milanese, Monza and Brianza, Italy.
Irene MagnificoAileens Pharma S.r.l., 20834 Nova Milanese, Monza and Brianza, Italy.
Marilina FalconeDepartment of Medicina e Scienze della Salute "V. Tiberio", Università degli Studi del Molise, 86100 Campobasso, Molise, Italy.
Natasha BrancazioDepartment of Medicina e Scienze della Salute "V. Tiberio", Università degli Studi del Molise, 86100 Campobasso, Molise, Italy.
Antonio GuarnieriDepartment of Medicina e Scienze della Salute "V. Tiberio", Università degli Studi del Molise, 86100 Campobasso, Molise, Italy.
Roberto Di MarcoDepartment of Drug and Health Sciences, Università degli Studi di Catania, 95125 Catania, Sicily, Italy.ORCID 0000-0001-5075-4597
Daria NicolosiDepartment of Drug and Health Sciences, Università degli Studi di Catania, 95125 Catania, Sicily, Italy.ORCID 0000-0003-4822-0363

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Living organisms must adapt and communicate effectively in their environment to survive. Cells communicate through various mechanisms, including releasing growth factors, chemokines, small bioactive molecules, and cell-cell contact. In recent years, a new and sophisticated cell communication mechanism based on extracellular vesicles (EVs) has been described in all three domains of life: archaea, bacteria, and eukaryotes. EVs are small, bilayer proteolipid vesicles released by cells into the extracellular space. This review aims to analyze and compare the current literature on bacterial, archaeal, and eukaryotic EVs and their possible clinical applications. This framework will address three key points: (a) The role of EVs in bacteria, eukaryotes, and archaea. (b) What is the impact of EVs in archaea on disease?

Indexed as

archaea EVsbacteria-derived extracellular vesiclescell communicationclinical applications of EVsextracellular vesiclesinterdomain communication

Identifiers

PMID40142528
PMCPMC11944275

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.