Evidence map›Paper›PMID 40142490›Full record

ArticleMicroorganisms2025

Lentinan Reduces Transmission Efficiency of COVID-19 by Changing Aerodynamic Characteristic of Exhaled SARS-CoV-2 Aerosols in Golden Hamsters.

Cheng Zhang, Jiaming Li, Huan Cui, Yifei Jin, Zhaoliang Chen, Lei Zhang, Sihui Song, Bing Lu, Zhongyi Wang, Zhendong Guo

Abstract read
In one paragraph

Article in Microorganisms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Viruses · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Cheng ZhangChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 573 Tulip Street, Changchun 130122, China.
Jiaming LiBeijing Institute of Biotechnology, 20 Dongdajie Road, Beijing 100071, China.
Huan CuiChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 573 Tulip Street, Changchun 130122, China.ORCID 0000-0002-7065-1285
Yifei JinBeijing Institute of Biotechnology, 20 Dongdajie Road, Beijing 100071, China.
Zhaoliang ChenChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 573 Tulip Street, Changchun 130122, China.
Lei ZhangChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 573 Tulip Street, Changchun 130122, China.
Sihui SongChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 573 Tulip Street, Changchun 130122, China.
Bing LuBeijing Institute of Biotechnology, 20 Dongdajie Road, Beijing 100071, China.
Zhongyi WangBeijing Institute of Biotechnology, 20 Dongdajie Road, Beijing 100071, China.ORCID 0000-0002-8982-2806
Zhendong GuoChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 573 Tulip Street, Changchun 130122, China.ORCID 0000-0001-8705-7744

Funding

National Key Research and Development Program of China 2023YFD1800403
6 · The paper itself

Abstract

Lentinan (LNT) was found to reduce the aerosol transmission rate between golden hamsters from 100% (9/9) to 44.4% (4/9). The viral loads in the respiratory system, including the nasal turbinate, trachea, and lung, were significantly reduced in the infected golden hamsters that received LNT treatment. Furthermore, the amount of exhaled virus aerosols in hamsters treated with LNT was significantly lower than that in untreated hamsters throughout the entire disease progression. In detail, the amounts of virus-laden particles with aerodynamic diameters less than 5 µm exhibited a significant decreasing trend following LNT treatment. Moreover, the detection rate of infectious SARS-CoV-2 in each stage of the Anderson-6 sampler exhibited a decreasing trend following LNT treatment post-infection. In summary, our findings indicate that LNT therapy represents a promising therapeutic candidate for the treatment of COVID-19 patients. Meanwhile, during the course of treatment, LNT has the potential to reduce viral infectivity in affected individuals.

Indexed as

aerodynamic diametersaerosol transmissibilityexhaled virus aerosolslentinan

Identifiers

PMID40142490
PMCPMC11944727

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.