Searching for a Solution: A Case Report on Multifocal Ectopic Purkinje-Related Premature Contractions Syndrome.

Monika Keževičiūtė, Neringa Bileišienė, Violeta Mikštienė, Germanas Marinskis, Jūratė Barysienė

Abstract readCase Reports

In one paragraph

Article in Medicina (Kaunas, Lithuania), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Think SCN5A: A novel variant causing multifocal Purkinje PVCs and dilated cardiomyopathy.Indian pacing and electrophysiology journal
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Monika KeževičiūtėClinic of Cardiac and Vascular Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Santariskiu str. 2, LT-08661 Vilnius, Lithuania.ORCID 0000-0003-4475-0228

Neringa BileišienėClinic of Cardiac and Vascular Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Santariskiu str. 2, LT-08661 Vilnius, Lithuania.

Violeta MikštienėDepartment of Human and Medical Genetics, Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University, Santariskiu g. 2, LT-08661 Vilnius, Lithuania.ORCID 0000-0002-3852-573X

Germanas MarinskisClinic of Cardiac and Vascular Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Santariskiu str. 2, LT-08661 Vilnius, Lithuania.ORCID 0000-0002-7439-9478

Jūratė BarysienėClinic of Cardiac and Vascular Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Santariskiu str. 2, LT-08661 Vilnius, Lithuania.ORCID 0009-0001-1600-9355

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multifocal ectopic Purkinje-related premature contractions (MEPPC) syndrome is a recently recognized rare form of arrhythmia involving the entire His-Purkinje system and often coinciding with dilated cardiomyopathy (DCM). Certain variants in the SCN5A gene may be linked to MEPPC syndrome. We present a case of a 32-year-old Caucasian female who exhibited a high burden of premature ventricular contractions (PVCs) and non-sustained episodes of ventricular tachycardia (NSVT) with an alternating QRS pattern, and who was resistant to traditional medical therapy and radiofrequency catheter ablation (RFCA), necessitating implantation of a cardioverter-defibrillator (ICD). A positive family history (father's death at the age of 40 years) and the rapid deterioration of left ventricular function parameters echocardiographically during recurrent arrhythmic episodes raised concern about a potentially complex disease scenario. Genetic testing revealed a heterozygous variant of the SCN5A gene,

Indexed as

Purkinje FibersVentricular Premature ComplexesAdultAnti-Arrhythmia AgentsCardiomyopathy, DilatedElectrocardiographyFemaleHumansMexiletineNAV1.5 Voltage-Gated Sodium ChannelAnti-Arrhythmia AgentsMexiletineNAV1.5 Voltage-Gated Sodium ChannelSCN5A protein, humancase reportdilated cardiomyopathymultifocal ectopic Purkinje-related premature contractionsmutationSCN5Aventricular tachycardia

Identifiers

PMID40142204

DOI10.3390/medicina61030393

PMCPMC11943923

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.