Evidence map›Paper›PMID 40142141›Full record

ArticleMolecules (Basel, Switzerland)2025

Good Manufacturing Practice Validation and Radiation Dosimetry for the Clinical Application of a Novel α7-nAChR Radioligand: [

Zhisheng Jia, Martin Bolin, Anton Forsberg Morén, Prodip Datta, Heba Asem, Hans Ågren, Bengt Långström, Agneta Nordberg, Christer Halldin, Sangram Nag

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zhisheng JiaDepartment of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet and Stockholm County Council, 171 77 Stockholm, Sweden.ORCID 0009-0002-3913-1078
Martin BolinDepartment of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet and Stockholm County Council, 171 77 Stockholm, Sweden.ORCID 0000-0002-7728-6401
Anton Forsberg MorénDepartment of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet and Stockholm County Council, 171 77 Stockholm, Sweden.
Prodip DattaDepartment of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet and Stockholm County Council, 171 77 Stockholm, Sweden.
Heba AsemDepartment of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet and Stockholm County Council, 171 77 Stockholm, Sweden.ORCID 0000-0001-8887-9141
Hans ÅgrenDivision of X-ray Photon Science, Uppsala University, 751 20 Uppsala, Sweden.ORCID 0000-0002-1763-9383
Bengt LångströmDepartment of Chemistry, Uppsala University, 751 20 Uppsala, Sweden.
Agneta NordbergDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 141 52 Stockholm, Sweden.ORCID 0000-0001-7345-5151
Christer HalldinDepartment of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet and Stockholm County Council, 171 77 Stockholm, Sweden.
Sangram NagDepartment of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet and Stockholm County Council, 171 77 Stockholm, Sweden.ORCID 0000-0003-3590-4256

Funding

Swedish Foundation for Strategic Research SSF, RB13-0192, VR 2017-06086 PI A.Nordberg
6 · The paper itself

Abstract

Nicotinic acetylcholine receptor (α7-nAChR) plays a crucial role in cognitive functions like memory and attention. Positron emission tomography (PET) imaging of α7-nAChR is gaining attraction for understanding and monitoring central nervous system disorders, such as Alzheimer's disease, Parkinson's disease, and schizophrenia. We developed [

Indexed as

alpha7 Nicotinic Acetylcholine ReceptorCarbon RadioisotopesRadiometryRadiopharmaceuticalsAnimalsFemaleHumansMacaca fascicularisPositron-Emission Tomographyalpha7 Nicotinic Acetylcholine ReceptorCarbon RadioisotopesRadiopharmaceuticalsAlzheimer’s diseasedosimetrynicotinic acetylcholine receptornon-human primatePET

Identifiers

PMID40142141
PMCPMC11945799

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.