ArticleMolecules (Basel, Switzerland)2025
Isolation, Chemical Characterization, and Antimicrobial Activity of Secondary Metabolites from
Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionAntimicrobial resistance is a global threat, highlighting the urgent need for novel antimicrobial agents. Among the mechanisms of resistance, bacteria can release drug-degrading enzymes and express efflux pumps, as well as grow in protected aggregates known as biofilms.
aimsTo identify and characterize the major metabolites present in
methodsThe molecules were purified by column chromatography and characterized by NMR spectroscopy. The antimicrobial activity of the compounds was determined in terms of proliferation, adhesion, and viability against
resultsThe major metabolites were spectroscopically characterized and identified as physciosporin and methyl virensate. Physciosporin showed antimicrobial activity on
conclusionsThis is the first report on the study of the antimicrobial activity of these compounds. Physciosporin showed promising activity in preventing the formation of
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