Evidence map›Paper›PMID 40142121›Full record

ArticleMolecules (Basel, Switzerland)2025

Synthesis, Characterization, and Antioxidant Activity Evaluation of New N-Methyl Substituted Thiazole-Derived Polyphenolic Compounds.

Alexandra Cătălina Cornea, Gabriel Marc, Ioana Ionuț, Cristina Moldovan, Anca Stana, Smaranda Dafina Oniga, Adrian Pîrnău, Laurian Vlase, Ilioara Oniga, Ovidiu Oniga

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alexandra Cătălina CorneaDepartment of Pharmaceutical Chemistry, "Iuliu Hațieganu" University of Medicine and Pharmacy, 41 Victor Babeș Street, RO-400012 Cluj-Napoca, Romania.
Gabriel MarcDepartment of Organic Chemistry, "Iuliu Hațieganu" University of Medicine and Pharmacy, 41 Victor Babeș Street, RO-400012 Cluj-Napoca, Romania.ORCID 0000-0001-9397-0388
Ioana IonuțDepartment of Pharmaceutical Chemistry, "Iuliu Hațieganu" University of Medicine and Pharmacy, 41 Victor Babeș Street, RO-400012 Cluj-Napoca, Romania.
Cristina MoldovanDepartment of Pharmaceutical Chemistry, "Iuliu Hațieganu" University of Medicine and Pharmacy, 41 Victor Babeș Street, RO-400012 Cluj-Napoca, Romania.
Anca StanaDepartment of Pharmaceutical Chemistry, "Iuliu Hațieganu" University of Medicine and Pharmacy, 41 Victor Babeș Street, RO-400012 Cluj-Napoca, Romania.ORCID 0000-0002-8453-3642
Smaranda Dafina OnigaDepartment of Therapeutic Chemistry, "Iuliu Hațieganu" University of Medicine and Pharmacy, 12 Ion Creangă Street, RO-400010 Cluj-Napoca, Romania.ORCID 0000-0002-0297-7697
Adrian PîrnăuNational Institute for Research and Development of Isotopic and Molecular Technologies, 67-103 Donath Street, RO-400293 Cluj-Napoca, Romania.ORCID 0000-0002-2313-9350
Laurian VlaseDepartment of Pharmaceutical Technology and Biopharmaceutics, "Iuliu Hațieganu" University of Medicine and Pharmacy, 41 Victor Babeș Street, RO-400012 Cluj-Napoca, Romania.ORCID 0000-0002-0664-3387
Ilioara OnigaDepartment of Pharmacognosy, "Iuliu Hațieganu" University of Medicine and Pharmacy, 12 Ion Creangă Street, RO-400010 Cluj-Napoca, Romania.ORCID 0000-0002-7660-9993
Ovidiu OnigaDepartment of Pharmaceutical Chemistry, "Iuliu Hațieganu" University of Medicine and Pharmacy, 41 Victor Babeș Street, RO-400012 Cluj-Napoca, Romania.

Funding

"Iuliu Hațieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania 771/17/11.01.2023, 647/17/11.01.2024MEC of Romania Installations and Special Objectives of National Interest (IOSIN), IZOSTABNational Research Development and Innovation Plan 2022-2027, Romania, carried out with the support of MEC "Nucleu" Program 27N/03.01.2023, component project code PN 23 24 01 05
6 · The paper itself

Abstract

Reactive oxygen species play a significant role in various pathological conditions, driving the need for novel, potent antioxidants. While polyphenols are known for their antioxidant properties, their limited stability and bioavailability present challenges for therapeutic applications. To address these limitations, a series of novel thiazolyl-polyphenolic compounds was synthesized via a multi-step synthetic route incorporating Hantzsch heterocyclization in the final step. The synthesized compounds

Indexed as

AntioxidantsPolyphenolsThiazolesMolecular StructureStructure-Activity RelationshipThermodynamicsAntioxidantsPolyphenolsThiazolesantioxidantDFTHantzsch heterocyclizationin vitrooxidative stresspolyphenolsROSthiazole derivatives

Identifiers

PMID40142121
PMCPMC11944991

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.