Evidence map›Paper›PMID 40142115›Full record

ArticleMolecules (Basel, Switzerland)2025

Isolation of Allosteric Tryptase Inhibitor from Methanol Extract of Rhubarb and Enhancement of Its Tryptase Inhibitory Activity by Compounds That Were Screened by In Silico Screening.

Hidetoshi Fujii, Moeno Ito, Kentaro Nishioka, Katsutoshi Nishino, Takanao Otsuka, Kazuhiro Irie, Takashi Tanaka, Masaya Nagao

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hidetoshi FujiiGraduate School of Biostudies, Kyoto University, Kyoto 606-8502, Japan.
Moeno ItoGraduate School of Biostudies, Kyoto University, Kyoto 606-8502, Japan.
Kentaro NishiokaGraduate School of Biostudies, Kyoto University, Kyoto 606-8502, Japan.ORCID 0009-0005-4864-2584
Katsutoshi NishinoGraduate School of Biostudies, Kyoto University, Kyoto 606-8502, Japan.ORCID 0009-0003-4790-0006
Takanao OtsukaDepartment of Applied Chemistry and Biotechnology, Okayama University of Science, Okayama 700-0005, Japan.
Kazuhiro IrieGraduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan.ORCID 0000-0001-7109-8568
Takashi TanakaGraduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8521, Japan.ORCID 0000-0001-7762-7432
Masaya NagaoGraduate School of Biostudies, Kyoto University, Kyoto 606-8502, Japan.ORCID 0000-0003-4006-0633

Funding

Japan Science and Technology Agency JPMJSA1506
6 · The paper itself

Abstract

Tryptase, which is abundant in human mast cells and is involved in allergic inflammations such as asthma, is a serine protease. We isolated a tryptase inhibitor, procyanidin B8 3,3'-di-

Indexed as

Plant ExtractsRheumSerine Proteinase InhibitorsTryptasesAllosteric RegulationComputer SimulationHumansHydrolyzable TanninsKineticsMethanolMolecular Docking SimulationHydrolyzable TanninsMethanolPlant ExtractsSerine Proteinase InhibitorsTryptasesallosteric inhibitorin silico screeningrhubarbtannintryptase

Identifiers

PMID40142115
PMCPMC11944477

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.