Evidence map›Paper›PMID 40142099›Full record

ArticleMolecules (Basel, Switzerland)2025

Natural Flavonoids from Licorice as Potent Inhibitors of β-Glucuronidase Elucidated Through Computational Studies.

Jingli Liu, Yingying Xue, Hao Yan, Jing Zhou, Xu Long, Yuping Tang

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jingli LiuCollege of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, China.
Yingying XueCollege of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, China.
Hao YanCollege of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, China.
Jing ZhouCollege of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, China.
Xu LongCollege of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, China.
Yuping TangKey Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility, Shaanxi University of Chinese Medicine, Xianyang 712046, China.

Funding

GHfund B ghfund202407028707the National Natural Science Foundation of China 82274084the Scientific Research Program funded by the Shaanxi University of Chinese Medicine 2023GP33Xianyang Innovation Team of Innovation Capability Support Program L2023-CXNL-CXTD-004
6 · The paper itself

Abstract

Gut bacterial β-glucuronidase is an important molecular target in several therapeutic applications. β-glucuronidase inhibitors can effectively alleviate gastrointestinal toxicity caused by certain drugs. Licorice, a traditional Chinese medicine, harmonizes various herbs and mitigates the toxicity of hundreds of herbs. In this study, a comprehensive computational strategy was employed to evaluate four licorice flavonoids (liquiritigenin, isoliquiritigenin, liquiritin, and isoliquiritin) as potential

Indexed as

Enzyme InhibitorsFlavonoidsGlucuronidaseGlycyrrhizaChalconesEscherichia coliFlavanonesGlucosidesGlycoproteinsMolecular Docking SimulationMolecular Dynamics Simulationbeta-glucuronidase inhibitorChalconesEnzyme InhibitorsFlavanonesFlavonoidsGlucosidesGlucuronidaseGlycoproteinsisoliquiritigeninliquiritigeninliquiritinfree energy calculationinhibitorslicorice flavonoidsmolecular dockingmolecular dynamics simulationβ-glucuronidase

Identifiers

PMID40142099
PMCPMC11945163

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.