Evidence map›Paper›PMID 40142037›Full record

ArticleMolecules (Basel, Switzerland)2025

Immunomodulatory Properties of Sweet Whey-Derived Peptides in THP-1 Macrophages.

Eleni Dalaka, Georgios C Stefos, Ioannis Politis, Georgios Theodorou

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Eleni DalakaLaboratory of Animal Breeding and Husbandry, Department of Animal Science, Agricultural University of Athens, 11855 Athens, Greece.
Georgios C StefosLaboratory of Animal Breeding and Husbandry, Department of Animal Science, Agricultural University of Athens, 11855 Athens, Greece.
Ioannis PolitisLaboratory of Animal Breeding and Husbandry, Department of Animal Science, Agricultural University of Athens, 11855 Athens, Greece.
Georgios TheodorouLaboratory of Animal Breeding and Husbandry, Department of Animal Science, Agricultural University of Athens, 11855 Athens, Greece.ORCID 0000-0002-7460-6035

Funding

European Regional Development Fund MIS 5033108State Scholarships Foundation MIS-5000432
6 · The paper itself

Abstract

Sweet whey (SW), a by-product of cheese production, has potential immunomodulatory properties that could be beneficial in preventing inflammation-related diseases. This study investigated the effects of SW derived from bovine, caprine, ovine, or an ovine/caprine mixture of milk on inflammation-related gene expression in THP-1-derived macrophages, both with and without LPS stimulation. Cells were treated with SW-D-P3 (a fraction smaller than 3 kDa produced by in vitro digestion), and the expression of inflammation-related genes was assessed using quantitative PCR. Results showed that the expression of

Indexed as

Immunologic FactorsMacrophagesPeptidesWheyWhey ProteinsAnimalsCattleCytokinesGene Expression RegulationGoatsHumansInflammationIntercellular Adhesion Molecule-1LipopolysaccharidesSheepTHP-1 CellsCytokinesImmunologic FactorsIntercellular Adhesion Molecule-1LipopolysaccharidesPeptidesToll-Like Receptor 2Whey Proteinscheese wheyinflammationINFOGESTqPCR

Identifiers

PMID40142037
PMCPMC11944360

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.