Evidence map›Paper›PMID 40141943›Full record

ArticleMicromachines2025

Efficient Particle Capture and Release Method for DNA Library Preparation on Microfluidics.

Zihan Song, Yihui Wu, Fengfeng Shu, Xiao Lv, Junyu Dong, Huan Li

Abstract read
In one paragraph

Article in Micromachines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zihan SongChangchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033, China.
Yihui WuChangchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033, China.
Fengfeng ShuChangchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033, China.
Xiao LvChangchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033, China.ORCID 0009-0007-0183-2094
Junyu DongChangchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033, China.
Huan LiChangchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033, China.

Funding

The National Key R&D Program of China 2021YFC2800300
6 · The paper itself

Abstract

To address the issues of agglomeration during magnetic particle capture and the incomplete release of these particles during reuse in microfluidic chips for library preparation, a microchamber was utilized to enhance the dispersion area for magnetic particle capture. Additionally, the release of magnetic particles was achieved through the synergistic action of flow field and magnetic field. The simulation results indicated that as the inlet flow velocity varied from 0.02 m/s to 0.16 m/s and the magnet spacing ranged from 1.2 mm to 1.8 mm, the coverage of magnetic particles in the microchamber increased from 17.29% to 63.59%. Meanwhile, the magnetic particle capture rate decreased from 100% to 35.2%. These processes were further validated through experimental methods. During the release process, the trajectory of magnetic particles under the synergistic effect of flow field and magnetic field aligned with expectations. The captured magnetic particles were released from the microchamber within 12 s, achieving a release rate of 100%.

Indexed as

hydrodynamicsmicrofluidicparticle releaseparticle separationsynergistic effect

Identifiers

PMID40141943
PMCPMC11946811

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.