Evidence map›Paper›PMID 40141938›Full record

ArticleMicromachines2025

Evaluation of Perfusion Cell Culture Conditions in a Double-Layered Microphysiological System Using AI-Assisted Morphological Analysis.

Naokata Kutsuzawa, Tomomi Goto, Hiroko Nakamura, Miwa Maeda, Masaki Kinehara, Junko Sakagami, Hiroshi Kimura

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Micromachines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Organ-on-a-chip toxicology.Innovation (Cambridge (Mass.)) · 2026
    Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Naokata KutsuzawaMicro/Nano Technology Center, Tokai University, 4-1-1 Kitakaname, Hiratsuka 259-1292, Kanagawa, Japan.
Tomomi GotoMicro/Nano Technology Center, Tokai University, 4-1-1 Kitakaname, Hiratsuka 259-1292, Kanagawa, Japan.
Hiroko NakamuraMicro/Nano Technology Center, Tokai University, 4-1-1 Kitakaname, Hiratsuka 259-1292, Kanagawa, Japan.
Miwa MaedaNikon Healthcare R&D Center Shonan, Nikon Corporation, Shonan Health Innovation Park, 2-26-1 Muraoka-higashi, Fujisawa 251-8555, Kanagawa, Japan.
Masaki KineharaNikon Healthcare R&D Center Shonan, Nikon Corporation, Shonan Health Innovation Park, 2-26-1 Muraoka-higashi, Fujisawa 251-8555, Kanagawa, Japan.
Junko SakagamiNikon Healthcare R&D Center Shonan, Nikon Corporation, Shonan Health Innovation Park, 2-26-1 Muraoka-higashi, Fujisawa 251-8555, Kanagawa, Japan.
Hiroshi KimuraMicro/Nano Technology Center, Tokai University, 4-1-1 Kitakaname, Hiratsuka 259-1292, Kanagawa, Japan.ORCID 0000-0003-0623-0248

Funding

Japanese Agency for Medical Research and Development JP22be1004101JSPS KAKENHI JP24K01321
6 · The paper itself

Abstract

In recent years, microphysiological systems (MPS) using microfluidic technology as a new in vitro experimental system have shown promise as an alternative to animal experiments in the development of drugs, especially in the field of drug discovery, and some reports have indicated that MPS experiments have the potential to be a valuable tool to obtain outcomes comparable to those of animal experiments. We have commercialized the Fluid3D-X

Indexed as

Caco-2Fluid3D-X®microfluidic chipmicrophysiological system

Identifiers

PMID40141938
PMCPMC11945015

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.