Evidence map›Paper›PMID 40141711›Full record

ReviewLife (Basel, Switzerland)2025

Enhancing Cervical Cancer Screening: New Diagnostic Methodologies, Triage, and Risk Stratification in Prevention and Treatment.

Nazira Kamzayeva, Gauri Bapayeva, Milan Terzic, Berik Primbetov, Balkenzhe Imankulova, Yevgeniy Kim, Arailym Sultanova, Kuralay Kongrtay, Nazira Kadroldinova, Talshyn Ukybassova

Abstract readReview
In one paragraph

Review in Life (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nazira KamzayevaClinical Academic Department of Women's Health, CF "University Medical Center", Astana 010000, Kazakhstan.ORCID 0009-0009-0229-2661
Gauri BapayevaClinical Academic Department of Women's Health, CF "University Medical Center", Astana 010000, Kazakhstan.ORCID 0000-0002-8344-7873
Milan TerzicClinical Academic Department of Women's Health, CF "University Medical Center", Astana 010000, Kazakhstan.ORCID 0000-0003-3914-5154
Berik PrimbetovClinical Academic Department of Women's Health, CF "University Medical Center", Astana 010000, Kazakhstan.
Balkenzhe ImankulovaClinical Academic Department of Women's Health, CF "University Medical Center", Astana 010000, Kazakhstan.
Yevgeniy KimClinical Academic Department of Women's Health, CF "University Medical Center", Astana 010000, Kazakhstan.
Arailym SultanovaClinical Academic Department of Internal Medicine, University Health Center, CF "University Medical Center", Astana 010000, Kazakhstan.
Kuralay KongrtayClinical Academic Department of Women's Health, CF "University Medical Center", Astana 010000, Kazakhstan.ORCID 0000-0002-1405-2245
Nazira KadroldinovaClinical Academic Department of Women's Health, CF "University Medical Center", Astana 010000, Kazakhstan.ORCID 0000-0003-4309-0432
Talshyn UkybassovaClinical Academic Department of Women's Health, CF "University Medical Center", Astana 010000, Kazakhstan.ORCID 0000-0002-5098-0727

Funding

Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan BR24992853
6 · The paper itself

Abstract

Human papillomavirus (HPV) is a well-established etiological factor in the development of precancerous cervical lesions and cervical cancer. This narrative review synthesizes current evidence on the global prevalence, genotype distribution, and pathophysiological mechanisms of HPV infection, emphasizing regional epidemiological variations that influence prevention and treatment strategies. Particular attention is given to high-risk HPV genotypes, their role in carcinogenesis, and the impact of co-infections and the cervicovaginal microbiota on infection persistence and disease progression. Advances in diagnostic methodologies, including E6/E7 oncoprotein detection, DNA methylation, and microRNA-based assays, are examined in the context of improving screening accuracy and early detection. Furthermore, the review explores the psychological implications of HPV diagnosis and underscores the importance of integrating psychosocial support into clinical management. Given the challenges associated with screening coverage, the potential of self-sampling techniques, particularly in resource-limited settings, is discussed as a means to enhance accessibility and participation in cervical cancer prevention programs. By providing a comprehensive overview of these interrelated factors, this review highlights the necessity of a multidisciplinary approach that integrates novel diagnostic strategies, targeted prevention efforts, and supportive care to mitigate the burden of HPV-associated diseases.

Indexed as

cervical cancerdiagnostic biomarkersHPVhuman papillomavirusmicrobiotapersistent HPV infectionprecancerous cervical lesionsscreeningself-sampling

Identifiers

PMID40141711
PMCPMC11943656

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.