Evidence map›Paper›PMID 40141698›Full record

ArticleLife (Basel, Switzerland)2025

Cytological Analysis of Upper Respiratory Tract Epithelial Cells in Chrysotile Asbestos Factory Workers.

Yertay Otarov, Zhengisbek Zharylkassyn, Altynay Shaibek, Manara Mukasheva, Zhanbol Sabirov, Alexey Alexeyev, Asset Izdenov, Chingiz Ismailov, Magzhan Tilemissov, Gulzhan Dossybayeva and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yertay OtarovNC JSC National Centre Occupational Health and Diseases, 15 Mustafin Street, Karaganda 100008, Kazakhstan.ORCID 0000-0001-5799-3451
Zhengisbek ZharylkassynSchool of Public Health, NC JSC Karaganda Medical University, 40 Gogol Street, Karaganda 100008, Kazakhstan.
Altynay ShaibekDepartment of Zoology, NC JSC Karagandy University named after E. A. Buketov, 28 University Street, Karaganda 100026, Kazakhstan.ORCID 0000-0002-8049-5781
Manara MukashevaDepartment of Physiology, NC JSC Karagandy University named after E. A. Buketov, 28 University Street, Karaganda 100026, Kazakhstan.
Zhanbol SabirovNC JSC National Centre Occupational Health and Diseases, 15 Mustafin Street, Karaganda 100008, Kazakhstan.ORCID 0000-0002-9922-3604
Alexey AlexeyevNC JSC National Centre Occupational Health and Diseases, 15 Mustafin Street, Karaganda 100008, Kazakhstan.ORCID 0000-0002-8988-3609
Asset IzdenovDepartment of Medical Education, Ministry of Healthcare of the Republic of Kazakhstan, Mangilik El str., 8, Astana 010000, Kazakhstan.
Chingiz IsmailovNC JSC National Centre Occupational Health and Diseases, 15 Mustafin Street, Karaganda 100008, Kazakhstan.
Magzhan TilemissovNC JSC National Centre Occupational Health and Diseases, 15 Mustafin Street, Karaganda 100008, Kazakhstan.
Gulzhan DossybayevaDepartment of General Practitioner-2, South Kazakhstan Pharmaceutical Academy, Al-Farabi Square 1, Shymkent 160019, Kazakhstan.
Nurzhamal ZhaketayevaNursing Education School, NC JSC Karaganda Medical University, 40 Gogol Street, Karaganda 100008, Kazakhstan.
Ulbala ShaikhattarovaDepartment of Public Health and Scientific Research, Khoja Akhmet Yassawi International Kazakh-Turkish University, 73 Almaty Street, Turkestan 161200, Kazakhstan.ORCID 0000-0001-5852-960X

Funding

Ministry of Science and Higher Education of the Republic of Kazakhstan AP23490331
6 · The paper itself

Abstract

objectiveThis study aims to assess the impact of prolonged occupational exposure to chrysotile asbestos on the epithelial cells of the upper respiratory tract and the levels of surfactant protein D (SP-D) in female workers.

methodsBuccal epithelial cell samples were collected from 40 workers at JSC "Kostanay Minerals", fixed using the May-Grünwald method, and stained with the Romanowsky-Giemsa technique. SP-D levels were measured using an enzyme-linked immunosorbent assay (ELISA).

resultsWorkers exposed to asbestos dust exhibited a significant increase in cytological abnormalities and higher SP-D levels compared to the control group.

conclusionProlonged exposure to chrysotile-containing dust leads to degenerative changes in upper respiratory tract epithelial cells, characterized by cytological and cytogenetic abnormalities, alongside elevated SP-D levels, highlighting the need for preventive health measures.

Indexed as

buccal epitheliumchrysotilemicronucleisurfactant protein D

Identifiers

PMID40141698
PMCPMC11943742

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.