Evidence map›Paper›PMID 40141690›Full record

ReviewLife (Basel, Switzerland)2025

The Neuroscience Behind Writing: Handwriting vs. Typing-Who Wins the Battle?

Giuseppe Marano, Georgios D Kotzalidis, Francesco Maria Lisci, Maria Benedetta Anesini, Sara Rossi, Sara Barbonetti, Andrea Cangini, Alice Ronsisvalle, Laura Artuso, Cecilia Falsini and 10 more

Abstract readReview
In one paragraph

Review in Life (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Brain organization of a memory champion.bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Giuseppe MaranoUnit of Psychiatry, Fondazione Policlinico Universitario AgostinoGemelli IRCCS, 00168 Rome, Italy.
Georgios D KotzalidisUnit of Psychiatry, Fondazione Policlinico Universitario AgostinoGemelli IRCCS, 00168 Rome, Italy.ORCID 0000-0002-0281-6324
Francesco Maria LisciUnit of Psychiatry, Fondazione Policlinico Universitario AgostinoGemelli IRCCS, 00168 Rome, Italy.ORCID 0000-0002-3314-142X
Maria Benedetta AnesiniUnit of Psychiatry, Fondazione Policlinico Universitario AgostinoGemelli IRCCS, 00168 Rome, Italy.ORCID 0009-0005-5839-1301
Sara RossiUnit of Psychiatry, Fondazione Policlinico Universitario AgostinoGemelli IRCCS, 00168 Rome, Italy.
Sara BarbonettiUnit of Psychiatry, Fondazione Policlinico Universitario AgostinoGemelli IRCCS, 00168 Rome, Italy.ORCID 0009-0005-8221-2721
Andrea CanginiFondazione Luigi Einaudi, 00193 Rome, Italy.
Alice RonsisvalleAccademia di Psicologia e Espressione Della Scrittura, 00168 Rome, Italy.
Laura ArtusoAccademia di Psicologia e Espressione Della Scrittura, 00168 Rome, Italy.
Cecilia FalsiniUnit of Psychiatry, Fondazione Policlinico Universitario AgostinoGemelli IRCCS, 00168 Rome, Italy.
Romina CasoUnit of Psychiatry, Fondazione Policlinico Universitario AgostinoGemelli IRCCS, 00168 Rome, Italy.
Giuseppe MandracchiaUnit of Psychiatry, Fondazione Policlinico Universitario AgostinoGemelli IRCCS, 00168 Rome, Italy.
Caterina BrisiUnit of Psychiatry, Fondazione Policlinico Universitario AgostinoGemelli IRCCS, 00168 Rome, Italy.
Gianandrea TraversiUnit of Medical Genetics, Department of Laboratory Medicine, Ospedale Isola Tiberina-Gemelli Isola, 00186 Rome, Italy.ORCID 0000-0002-6558-2932
Osvaldo MazzaSpine Surgery Department, Bambino Gesù Children's Hospital IRCCS, 00168 Rome, Italy.
Roberto PolaSection of Internal Medicine and Thromboembolic Diseases, Department of Internal Medicine, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.ORCID 0000-0001-5224-2931
Gabriele SaniUnit of Psychiatry, Fondazione Policlinico Universitario AgostinoGemelli IRCCS, 00168 Rome, Italy.ORCID 0000-0002-9767-8752
Eugenio Maria MercuriDepartment Women Children and Public Health, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Eleonora GaetaniDepartment of Translational Medicine and Surgery, Fondazione Policlinico Universitario AgostinoGemelli IRCCS Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Marianna MazzaUnit of Psychiatry, Fondazione Policlinico Universitario AgostinoGemelli IRCCS, 00168 Rome, Italy.ORCID 0000-0002-3007-8162

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe advent of digital technology has significantly altered ways of writing. While typing has become the dominant mode of written communication, handwriting remains a fundamental human skill, and its profound impact on cognitive processes continues to be a topic of intense scientific scrutiny.

methodsThis paper investigates the neural mechanisms underlying handwriting and typing, exploring the distinct cognitive and neurological benefits associated with each. By synthesizing findings from neuroimaging studies, we explore how handwriting and typing differentially activate brain regions associated with motor control, sensory perception, and higher-order cognitive functions.

resultsHandwriting activates a broader network of brain regions involved in motor, sensory, and cognitive processing. Typing engages fewer neural circuits, resulting in more passive cognitive engagement. Despite the advantages of typing in terms of speed and convenience, handwriting remains an important tool for learning and memory retention, particularly in educational contexts.

conclusionsThis review contributes to the ongoing debate about the role of technology in education and cognitive development. By understanding the neural differences between handwriting and typing, we can gain insights into optimal learning strategies and potential cognitive advantages, in order to optimize educational, cognitive, and psychological methodologies.

Indexed as

cognitionelectroencephalographyfunctionalhandwritingmagnetic resonance imagingtyping

Identifiers

PMID40141690
PMCPMC11943480

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.