Evidence map›Paper›PMID 40141425›Full record

ArticleInternational journal of molecular sciences2025

Identification of a Selective Inhibitor of Human NFS1, a Cysteine Desulfurase Involved in Fe-S Cluster Assembly, via Structure-Based Virtual Screening.

Zhilong Zhu, Haisheng Gan, Yanxiong Wang, Guanya Jia, Heng Li, Zhiwei Ma, Jun Wang, Xiaoya Shang, Weining Niu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhilong ZhuSchool of Life Sciences, Northwestern Polytechnical University, Xi'an 710072, China.
Haisheng GanSchool of Life Sciences, Northwestern Polytechnical University, Xi'an 710072, China.
Yanxiong WangSchool of Life Sciences, Northwestern Polytechnical University, Xi'an 710072, China.
Guanya JiaSchool of Life Sciences, Northwestern Polytechnical University, Xi'an 710072, China.
Heng LiSchool of Life Sciences, Northwestern Polytechnical University, Xi'an 710072, China.
Zhiwei MaSchool of Life Sciences, Northwestern Polytechnical University, Xi'an 710072, China.
Jun WangSchool of Life Sciences, Northwestern Polytechnical University, Xi'an 710072, China.
Xiaoya ShangSchool of Life Sciences, Northwestern Polytechnical University, Xi'an 710072, China.
Weining NiuSchool of Life Sciences, Northwestern Polytechnical University, Xi'an 710072, China.

Funding

Key Research and Development Program of Shaanxi 2023-YBSF-107; 2024NC-YBXM-187National Natural Science Foundation of China 31871145Natural Science Basic Research Plan in Shaanxi Province of China 2023-JC-QN-0244Science and Technology Program of Xi'an City 24KGDW0007; 24GXFW0081-09; 22GXFW0137
6 · The paper itself

Abstract

Human cysteine desulfurase (NFS1) participates in numerous critical cellular processes, including iron-sulfur (Fe-S) cluster biosynthesis and tRNA thiolation. NFS1 overexpression has been observed in a variety of cancers, and thus it has been considered a promising anti-tumor therapeutic target. To date, however, no inhibitors targeting NFS1 have been identified. Here, we report the identification of the first potent small-molecule inhibitor (Compound

Indexed as

Carbon-Sulfur LyasesEnzyme InhibitorsIron-Sulfur ProteinsA549 CellsAntineoplastic AgentsCell ProliferationHumansIronMolecular Docking SimulationReactive Oxygen SpeciesAntineoplastic AgentsCarbon-Sulfur Lyasescysteine desulfuraseEnzyme InhibitorsIronIron-Sulfur ProteinsNFS1 protein, humanReactive Oxygen Speciescysteine desulfurase (NFS1)ferroptosisFe-S clusterinhibitormolecular dockingvirtual screening

Identifiers

PMID40141425
PMCPMC11942905

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.