Evidence map›Paper›PMID 40141410›Full record

ArticleInternational journal of molecular sciences2025

Pulmonary Myeloid Cells in Mild Cases of COVID-19 Upregulate the Intracellular Fc Receptor

Andrea Henriques-Pons, Maria Clicia S Castro, Vanessa S Silva, Maiana O C Costa, Helena S I L Silva, Maria Emilia M T Walter, Anna Cristina C Carvalho, Alba C M A Melo, Kary Ocaña, Marcelo T Dos Santos and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Andrea Henriques-PonsLaboratory of Innovations in Therapies, Education and Bioproducts, Oswaldo Cruz Foundation, Rio de Janeiro 21040-900, Brazil.ORCID 0000-0001-9136-240X
Maria Clicia S CastroDepartment of Informatics and Computer Science, State University of Rio de Janeiro, Rio de Janeiro 20550-900, Brazil.ORCID 0000-0002-6315-1215
Vanessa S SilvaScientific Computing Program, Oswaldo Cruz Foundation, Rio de Janeiro 21040-900, Brazil.
Maiana O C CostaComputational Modeling Department, National Laboratory for Scientific Computing, Petropolis 15651-075, Brazil.
Helena S I L SilvaDepartment of Computer Science, University of Brasilia, Campus Universitário Darcy Ribeiro, Brasilia 70910-900, Brazil.
Maria Emilia M T WalterDepartment of Computer Science, University of Brasilia, Campus Universitário Darcy Ribeiro, Brasilia 70910-900, Brazil.
Anna Cristina C CarvalhoLaboratory of Innovations in Therapies, Education and Bioproducts, Oswaldo Cruz Foundation, Rio de Janeiro 21040-900, Brazil.ORCID 0000-0002-0128-942X
Alba C M A MeloDepartment of Computer Science, University of Brasilia, Campus Universitário Darcy Ribeiro, Brasilia 70910-900, Brazil.
Kary OcañaComputational Modeling Department, National Laboratory for Scientific Computing, Petropolis 15651-075, Brazil.
Marcelo T Dos SantosComputational Modeling Department, National Laboratory for Scientific Computing, Petropolis 15651-075, Brazil.ORCID 0000-0002-7083-0435
Marisa F NicolasComputational Modeling Department, National Laboratory for Scientific Computing, Petropolis 15651-075, Brazil.ORCID 0000-0002-5437-2737
Fabrício A B SilvaScientific Computing Program, Oswaldo Cruz Foundation, Rio de Janeiro 21040-900, Brazil.ORCID 0000-0002-8172-5796

Funding

fundação oswaldo cruz VPPCB-005-FIO-20-2-34-52
6 · The paper itself

Abstract

Much remains to be understood about COVID-19, but the protective role of antibodies (Igs) is widely accepted in SARS-CoV-2 infection. Igs' functions are mainly carried out by receptors that bind to their Fc portion (FcR), and less attention has been dedicated to the cytoplasmic members of this family. In this work, we used single-cell RNA sequencing (scRNA-seq) data to discern cell populations in bronchoalveolar lavage fluid obtained from healthy individuals and patients with mild or severe COVID-19. Then, we evaluated the transcription of neonatal FcR (FcRn,

Indexed as

COVID-19LungMyeloid CellsProteasome Endopeptidase ComplexReceptors, FcRibonucleoproteinsAdultAgedBronchoalveolar Lavage FluidFemaleHumansMaleMiddle AgedSARS-CoV-2Signal TransductionSS-A AntigenProteasome Endopeptidase ComplexReceptors, FcRibonucleoproteinsSS-A AntigenCOVID-19Fc receptorsinflammatory responsescRNA-seqTRIM21

Identifiers

PMID40141410
PMCPMC11943277

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.