Evidence map›Paper›PMID 40141387›Full record

ArticleInternational journal of molecular sciences2025

Identification of a Novel Antagonist of BRS-3 from Natural Products and Its Protective Effects Against H

Jihong Lu, Lehao Wu, Jianzheng Zhu, Han Zhou, Mingzhu Fang, Hongshuo Liang, Miao Guo, Mo Chen, Yuhang Zhu, Jixia Wang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jihong LuShanghai Frontiers Science Center of Drug Target Identification and Delivery, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.
Lehao WuShanghai Frontiers Science Center of Drug Target Identification and Delivery, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.ORCID 0000-0003-0127-2609
Jianzheng ZhuState Key Laboratory of Microbial Metabolism, Joint International Research Laboratory Metabolic & Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
Han ZhouKey Laboratory of Phytochemistry and Natural Medicines, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
Mingzhu FangShanghai Frontiers Science Center of Drug Target Identification and Delivery, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.
Hongshuo LiangShanghai Frontiers Science Center of Drug Target Identification and Delivery, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.
Miao GuoState Key Laboratory of Microbial Metabolism, Joint International Research Laboratory Metabolic & Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
Mo ChenShanghai Frontiers Science Center of Drug Target Identification and Delivery, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.
Yuhang ZhuZhiyuan College, Shanghai Jiao Tong University, Shanghai 200240, China.
Jixia WangKey Laboratory of Phytochemistry and Natural Medicines, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
Hua XiaoState Key Laboratory of Microbial Metabolism, Joint International Research Laboratory Metabolic & Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
Yan ZhangShanghai Frontiers Science Center of Drug Target Identification and Delivery, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.

Funding

National Natural Science Foundation of China 22374098Natural Science Foundation of Shanghai 23ZR1434200, 19ZR1427800the Key Scientific Project of Shanghai Jiao Tong University TMSK-2020-130
6 · The paper itself

Abstract

The identification of exogenous ligands from natural products is an alternative strategy to explore the unrevealed physiological functions of orphan G-protein-coupled receptors (GPCRs). In this study, we have successfully identified and pharmacologically characterized licoisoflavone A (LIA) as a novel selective antagonist of BRS-3, an orphan GPCR. Functional studies showed that pretreatment with LIA ameliorated hydrogen peroxide (H

Indexed as

Biological ProductsHydrogen PeroxideMyocytes, CardiacProtective AgentsAnimalsCell LineHEK293 CellsHumansMaleMiceMice, KnockoutOxidative StressRatsSignal TransductionBiological ProductsHydrogen PeroxideProtective AgentsantagonistBRS-3cardiomyocytelicoisoflavone Aorphan GPCR

Identifiers

PMID40141387
PMCPMC11943355

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.