Evidence map›Paper›PMID 40141376›Full record

ArticleInternational journal of molecular sciences2025

TFRC Ablation Induces Insufficient Cartilage Development Through Mitochondrial p53 Translocation-Mediated Ferroptosis.

Yidi Wang, Xi Wen, Yutong Guo, Yixiang Wang, Yan Gu

Erratum issuedAbstract read
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In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. CD22Science China. Life sciences · 2026
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Yidi WangDepartment of Orthodontics, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, No. 22, Zhongguancun Avenue South, Haidian District, Beijing 100081, China.
Xi WenDepartment of Orthodontics, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, No. 22, Zhongguancun Avenue South, Haidian District, Beijing 100081, China.
Yutong GuoDepartment of Orthodontics, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, No. 22, Zhongguancun Avenue South, Haidian District, Beijing 100081, China.
Yixiang WangCentral Laboratory, Peking University School and Hospital of Stomatology, No. 22, Zhongguancun Avenue South, Haidian District, Beijing 100081, China.ORCID 0000-0001-5291-9826
Yan GuDepartment of Orthodontics, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, No. 22, Zhongguancun Avenue South, Haidian District, Beijing 100081, China.ORCID 0000-0003-0108-4325

Funding

National Natural Science Foundation of China 81970920National Natural Science Foundation of China 81970979Natural Science Foundation of Beijing Municipality 7232217Natural Science Foundation of Beijing Municipality 7232218Natural Science Foundation of Beijing Municipality 7254458
6 · The paper itself

Abstract

The mandibular condyle cartilage serves as a principal zone for mandible growth, and any dysplasia could contribute to skeletal mandibular hypoplasia (SMH). The aim of the study was to further explore how TFRC signaling regulates condylar cartilage development. In this study, TFRC, SLC39A14, chondrogenic markers and ferroptosis-related signals were detected in the condylar cartilage of postnatal mice and

Indexed as

CartilageChondrogenesisFerroptosisMitochondriaReceptors, TransferrinTumor Suppressor Protein p53AnimalsCartilage, ArticularCation Transport ProteinsCell LineChondrocytesMandibular CondyleMiceMice, KnockoutCation Transport ProteinsReceptors, TransferrinTfrc protein, mouseTrp53 protein, mouseTumor Suppressor Protein p53cartilage developmentchondrogenesisferroptosismitochondrial p53 translocationSLC39A14transferrin receptor 1 (TFRC)

Identifiers

PMID40141376
PMCPMC11943061

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.