ArticleInternational journal of molecular sciences2025
Transient Global Amnesia (TGA): Is It Really Benign? A Pilot Study on Blood Biomarkers.
Fabio Rossini, Tobias Moser, Michael Unterhofer, Michael Khalil, Rina Demjaha, Cansu Tafrali, Maria Martinez-Serrat, Jens Kuhle, David Leppert, Pascal Benkert and 3 more
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In one paragraphArticle in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
13 authors.
Fabio RossiniDepartment of Neurology, Neurocritical Care and Neurorehabilitation, Christian Doppler University Hospital, Paracelsus Medical University and Center for Cognitive Neuroscience, European Reference Network EpiCARE, 5020 Salzburg, Austria.
Tobias MoserDepartment of Neurology, Neurocritical Care and Neurorehabilitation, Christian Doppler University Hospital, Paracelsus Medical University and Center for Cognitive Neuroscience, European Reference Network EpiCARE, 5020 Salzburg, Austria.ORCID 0000-0002-5397-5595 Michael UnterhoferDepartment of Neurology, Neurocritical Care and Neurorehabilitation, Christian Doppler University Hospital, Paracelsus Medical University and Center for Cognitive Neuroscience, European Reference Network EpiCARE, 5020 Salzburg, Austria.ORCID 0009-0004-7262-942X Michael KhalilDepartment of Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036 Graz, Austria.ORCID 0000-0002-5350-3328 Rina DemjahaDepartment of Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036 Graz, Austria.
Cansu TafraliDepartment of Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036 Graz, Austria.
Maria Martinez-SerratDepartment of Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036 Graz, Austria.
Jens KuhleMultiple Sclerosis Centre and Research Center for Clinical Neuroimmunology and Neuroscience (RC2NB), Department of Biomedicine, University Hospital and University of Basel, 4031 Basel, Switzerland.
David LeppertMultiple Sclerosis Centre and Research Center for Clinical Neuroimmunology and Neuroscience (RC2NB), Department of Biomedicine, University Hospital and University of Basel, 4031 Basel, Switzerland.ORCID 0000-0001-6172-801X Pascal BenkertMultiple Sclerosis Centre and Research Center for Clinical Neuroimmunology and Neuroscience (RC2NB), Department of Biomedicine, University Hospital and University of Basel, 4031 Basel, Switzerland.
Johannes A R PfaffDepartment of Neuroradiology, Christian Doppler University Hospital, Paracelsus Medical University of Salzburg, 5020 Salzburg, Austria.ORCID 0000-0003-0672-5718 Eugen TrinkaDepartment of Neurology, Neurocritical Care and Neurorehabilitation, Christian Doppler University Hospital, Paracelsus Medical University and Center for Cognitive Neuroscience, European Reference Network EpiCARE, 5020 Salzburg, Austria.ORCID 0000-0002-5950-2692 Slaven PikijaDepartment of Neurology, Neurocritical Care and Neurorehabilitation, Christian Doppler University Hospital, Paracelsus Medical University and Center for Cognitive Neuroscience, European Reference Network EpiCARE, 5020 Salzburg, Austria.
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
We aimed to determine whether transient global amnesia (TGA) is associated with alterations in central nervous system (CNS) injury biomarkers-serum neurofilament light chain (sNfL) and serum glial fibrillary acidic protein (sGFAP). In a prospective cohort of TGA patients, blood samples were obtained within 24-48 h of TGA onset (t0) and 6 weeks thereafter (t1). We assessed sNfL and sGFAP levels using the highly sensitive single-molecule array assay and calculated Z-scores adjusted for age, gender, and body mass index (BMI). Demographics, electroencephalography (EEG), and cerebral magnetic resonance imaging (cMRI) findings were also collected. A total of 20 patients were included (median age: 66 years, 70% women). No significant changes in sNfL or sGFAP levels associated with TGA at t0 and t1 were observed. Median sNfL Z-scores were 0.45 (interquartile range [IQR] -0.09, 1.19) at t0 and 0.60 (IQR -0.61, 1.19) at t1. Median sGFAP Z-scores were 0.27 (IQR -0.45, 0.76) at t0 and 0.44 (IQR -0.27, 0.75) at t1. Similarly, in the subgroup of patients with diffusion-weighted imaging (DWI)-positive hippocampal lesions (
Indexed as
Amnesia, Transient GlobalBiomarkersGlial Fibrillary Acidic ProteinNeurofilament ProteinsAgedElectroencephalographyFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPilot ProjectsProspective StudiesBiomarkersGFAP protein, humanGlial Fibrillary Acidic Proteinneurofilament protein LNeurofilament Proteinscentral nervous systemglial fibrillary acidic proteinmemory disordersneurofilament light chainprognosisSimoaTGA
Identifiers
PMID40141275
PMCPMC11941937
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