Evidence map›Paper›PMID 40141268›Full record

ArticleInternational journal of molecular sciences2025

Cul2 Is Essential for the

Renjie Duan, Baoyi Hu, Erwen Ding, Shikun Zhang, Mingfei Wu, Yiheng Jin, Umar Ali, Muhammad Abdul Rehman Saeed, Badar Raza, Muhammad Usama and 3 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The functionalFrontiers in immunology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Renjie DuanCenter for Developmental Biology, School of Life Sciences, Anhui Agricultural University, Hefei 230036, China.
Baoyi HuCenter for Developmental Biology, School of Life Sciences, Anhui Agricultural University, Hefei 230036, China.
Erwen DingCenter for Developmental Biology, School of Life Sciences, Anhui Agricultural University, Hefei 230036, China.
Shikun ZhangCenter for Developmental Biology, School of Life Sciences, Anhui Agricultural University, Hefei 230036, China.
Mingfei WuCenter for Developmental Biology, School of Life Sciences, Anhui Agricultural University, Hefei 230036, China.
Yiheng JinCenter for Developmental Biology, School of Life Sciences, Anhui Agricultural University, Hefei 230036, China.
Umar AliCenter for Developmental Biology, School of Life Sciences, Anhui Agricultural University, Hefei 230036, China.
Muhammad Abdul Rehman SaeedCenter for Developmental Biology, School of Life Sciences, Anhui Agricultural University, Hefei 230036, China.
Badar RazaCenter for Developmental Biology, School of Life Sciences, Anhui Agricultural University, Hefei 230036, China.
Muhammad UsamaCenter for Developmental Biology, School of Life Sciences, Anhui Agricultural University, Hefei 230036, China.
Syeda Samia BatoolCenter for Developmental Biology, School of Life Sciences, Anhui Agricultural University, Hefei 230036, China.
Qingshuang CaiInstitut de Génétique et de Biologie Moléculaire et Cellulaire, 67400 Illkirch, France.
Shanming JiCenter for Developmental Biology, School of Life Sciences, Anhui Agricultural University, Hefei 230036, China.ORCID 0000-0002-3360-1203

Funding

National Natural Science Foundation of China 32100702
6 · The paper itself

Abstract

Cullin 2 (Cul2), a core component of the Cullin-RING E3 ubiquitin ligase complex, is integral to regulating distinct biological processes. However, its role in innate immune defenses remains poorly understood. In this study, we investigated the functional significance of Cul2 in the immune deficiency (IMD) signaling-mediated antimicrobial immune reactions in

Indexed as

Cullin ProteinsDrosophila melanogasterDrosophila ProteinsImmunity, InnateSignal TransductionAnimalsAntimicrobial PeptidesProteomicsAntimicrobial PeptidesCullin ProteinsDrosophila Proteinsimd protein, Drosophilaantimicrobial immune defenseCul2Drosophila melanogasterEffIMD signaling pathway

Identifiers

PMID40141268
PMCPMC11941880

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.